GRK4 抗体
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北京 101111
Quick Overview for GRK4 抗体 (ABIN2428193)
抗原
See all GRK4 抗体适用
宿主
克隆类型
标记
应用范围
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纯化方法
- Antigen affinity purification
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免疫原
- Recombinant protein of human GRK4
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亚型
- IgG
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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注意事项
- Avoid freeze / thaw cycles.
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储存条件
- -20 °C/-80 °C
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储存方法
- Store at -20°C (regular) and -80°C (long term).
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- GRK4 (G Protein-Coupled Receptor Kinase 4 (GRK4))
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别名
- GRK4
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背景
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This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating its deactivation. This gene has been linked to both genetic and acquired hypertension. Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can phosphorylate rhodopsin and its activity is inhibited by calmodulin, the other three isoforms do not phosphorylate rhodopsin and do not interact with calmodulin. GRK4-alpha and GRK4-gamma phosphorylate DRD3. Phosphorylates ADRB2.
Synonyms: IT11, GPRK4, GRK4a, GPRK2L -
分子量
- Calculated MW: 67 kDa
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途径
- Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling
抗原
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