Optimal working dilution should be determined by the investigator.
限制
仅限研究用
状态
Liquid
注意事项
Avoid freeze / thaw cycles.
储存条件
-20 °C/-80 °C
储存方法
Store at -20°C (regular) and -80°C (long term).
抗原
GRK4
(G Protein-Coupled Receptor Kinase 4 (GRK4))
别名
GRK4
背景
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating its deactivation. This gene has been linked to both genetic and acquired hypertension. Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can phosphorylate rhodopsin and its activity is inhibited by calmodulin, the other three isoforms do not phosphorylate rhodopsin and do not interact with calmodulin. GRK4-alpha and GRK4-gamma phosphorylate DRD3. Phosphorylates ADRB2. Synonyms: IT11, GPRK4, GRK4a, GPRK2L