NCOA3 抗体 (Internal Region)
Quick Overview for NCOA3 抗体 (Internal Region) (ABIN233839)
抗原
See all NCOA3 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Internal Region
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Supplier Product No.
- 600-401-a40
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Supplier
- Rockland
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原理
- NCOA3 Antibody
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交叉反应 （详细）
- This antibody reacts with several isoforms of human NCOA3 protein (a, b, d, e and f).
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产品特性
- Synonyms: rabbit anti-NCOA3 antibody, NCOA 3, NCOA-3, Nuclear receptor coactivator 3 NCoA-3, Thyroid hormone receptor activator molecule 1, TRAM-1, pCIP, bHLHe42, Receptor-associated coactivator 3, RAC-3, Amplified in breast cancer 1 protein, AIB-1, Steroid receptor coactivator protein 3, SRC-3, ACTR, AIB1, BHLHE42, RAC3, TRAM1
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纯化方法
- This product was affinity purified from monospecific antiserum by immunoaffinity chromatography.
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过滤
- Sterile filtered
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免疫原
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Immunogen: This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to an internal region of human NCOA3 isoform a protein.
Immunogen Type: Conjugated Peptide
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亚型
- IgG
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anti-Nuclear Receptor Coactivator 3 (NCOA3) (AA 1023-1304) antibody
NCOA3 适用: 人 WB, ELISA, IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Receptor Coactivator 3 (NCOA3) antibodyNCOA3 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Receptor Coactivator 3 (NCOA3) (AA 188-198) antibodyNCOA3 适用: 人, Cow, 犬, Pig, 猴, Bat, Hamster IHC, IHC (p) 宿主: 山羊 Polyclonal unconjugated
anti-Nuclear Receptor Coactivator 3 (NCOA3) (AA 576-625) antibodyNCOA3 适用: 人, Cow, Pig, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Receptor Coactivator 3 (NCOA3) (Internal Region) antibodyNCOA3 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Receptor Coactivator 3 (NCOA3) antibodyNCOA3 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 5H3 unconjugated
anti-Nuclear Receptor Coactivator 3 (NCOA3) (pThr24) antibodyNCOA3 适用: 人 ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Receptor Coactivator 3 (NCOA3) (AA 344-372), (N-Term) antibodyNCOA3 适用: 人 WB 宿主: 兔 Polyclonal RB41497 unconjugated
anti-Nuclear Receptor Coactivator 3 (NCOA3) antibodyNCOA3 适用: 人 WB, ChIP 宿主: 兔 Polyclonal unconjugated
anti-Nuclear Receptor Coactivator 3 (NCOA3) (AA 1-200) antibodyNCOA3 适用: 人 ELISA 宿主: 小鼠 Monoclonal 2C11B12 unconjugated
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应用备注
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Immunohistochemistry Dilution: 5 μg/mL
Application Note: This affinity purified antibody has been tested for use in ELISA, Immunohistochemistry, and western blotting. Specific conditions for reactivity should be optimized by the end user.
Western Blot Dilution: 1:500 - 1:1,000
Immunoprecipitation Dilution: 1:100
ELISA Dilution: 1:175,000
Other: User Optimized
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.82 mg/mL
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缓冲液
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Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Stabilizer: None
Preservative: 0.01 % (w/v) Sodium Azide -
储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
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有效期
- 12 months
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- NCOA3 (Nuclear Receptor Coactivator 3 (NCOA3))
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别名
- NCOA3
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背景
- Background: This antibody is designed, produced, and validated as part of a collaboration with the National Cancer Institute (NCI). The NCOA3 (also known as nuclear receptor coactivator 3 isoform a) is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions in a hormone-dependent fashion. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. NCOA3 probably acts via remodeling of chromatin and is involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). NCOA3 is also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit. NCOA3 may be associated with diseases such as breast cancer and meningothelial meningioma. Anti-NCOA3 Antibody is useful for researchers interested in cancer research, chromatin binding, transcription coactivator activity, Immunology, and Nuclear Signaling research.
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基因ID
- 8202, 32307126
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UniProt
- Q9Y6Q9
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途径
- Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Lipid Metabolism by PPARalpha
抗原
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