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THRA 抗体 (N-Term)

Name: THRA 抗体 (N-Term)
Brand: antibodies-online
SKU: ABIN233838
Availability: OutOfStock

THRA 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated

Western blot using affinity purified anti-THRA antibody shows detection of purified recombinant THRA (lane 1) and THRA present in a 293 cell lysate after transient transfection with THRA (lane 3). (THRA 抗体 (N-Term))

1 image

(2 references)

产品编号 ABIN233838

发货至: 中国

Datasheet as PDF

抗原 See all THRA 抗体

THRA (Thyroid Hormone Receptor, alpha (THRA))
抗原表位
16

8

6

3

3

1

1

1

1

1

1

1

1

1

1

1

1
N-Term
适用
61

30

30

8

5

4

4

4

4

4

3

3

2
人
宿主
40

20

1
兔
Compatible Secondaries
克隆类型
43

18
多克隆
标记
32

4

3

3

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
This THRA antibody is un-conjugated
应用范围
56

27

24

14

13

13

6

3

3

2

1

1
Western Blotting (WB), ELISA

特异性

This product was affinity purified from monospecific antiserum by immunoaffinity chromatography. This antibody reacts with human THRA protein. A BLAST analysis was used to suggest cross-reactivity with THRA from mouse, human and rat based on a 100% homology with the immunizing sequence. Cross-reactivity with THRA from other sources has not been determined.

产品特性

This antibody is designed, produced, and validated as part of a collaboration with the National Cancer Institute (NCI) and is suitable for Cancer, Immunology and Nuclear Signaling research. Thyroid hormone receptor alpha is a nuclear hormone receptor with high affinity for the hormone triiodo-thyronine. THRA is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having a certain extent of redundancy, may mediate different functions of thyroid hormone. THRA interacts with NCOA3 and NCOA6 co-activators, leading to a strong increase in transcription of target genes. THRA is localized within the nucleus and has been found to exist as 4 isoforms originating from alternative splicing variants. This antibody recognizes THRA isoform 1. Isoform 1 has a distinct C-terminus compared to isoform 2.

纯化方法

affinity purified

过滤

Sterile filtered

免疫原

This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to a region near the amino terminus of human THRA isoform 1 protein.
Immunogen Type: Peptide

亚型

IgG

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anti-Thyroid Hormone Receptor, alpha (THRA) antibody
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anti-Thyroid Hormone Receptor, alpha (THRA) antibody (HRP)
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anti-Thyroid Hormone Receptor, alpha (THRA) antibody (FITC)
THRA 适用: 人 WB, ELISA, IHC 宿主: 小鼠 Monoclonal H43 FITC

anti-Thyroid Hormone Receptor, alpha (THRA) antibody (Alkaline Phosphatase (AP))
THRA 适用: 人 WB, ELISA, IHC 宿主: 小鼠 Monoclonal H43 Alkaline Phosphatase (AP)

anti-Thyroid Hormone Receptor, alpha (THRA) antibody (Biotin)
THRA 适用: 人 WB, ELISA, IHC 宿主: 小鼠 Monoclonal H43 Biotin

anti-Thyroid Hormone Receptor, alpha (THRA) antibody (PE)
THRA 适用: 人 WB, ELISA, IHC 宿主: 小鼠 Monoclonal H43 PE

anti-Thyroid Hormone Receptor, alpha (THRA) antibody (PerCP)
THRA 适用: 人 WB, ELISA, IHC 宿主: 小鼠 Monoclonal H43 PerCP

anti-Thyroid Hormone Receptor, alpha (THRA) antibody (APC)
THRA 适用: 人 WB, ELISA, IHC 宿主: 小鼠 Monoclonal H43 APC

anti-Thyroid Hormone Receptor, alpha (THRA) antibody (Atto 594)
THRA 适用: 人 WB, ELISA, IHC 宿主: 小鼠 Monoclonal H43 Atto 594

应用备注

This affinity purified antibody has been tested for use in ELISA and western blotting.

说明

Gene Name: THRA

限制

仅限研究用
状态

Liquid

浓度

0.89 mg/mL

缓冲液

0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

储存液

Sodium azide

注意事项

This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C/-20 °C

储存方法

Store vial at 4 °C prior to restoration. For extended storage aliquot contents and freeze at -20 °C or below. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4 °C as an undiluted liquid. Dilute only prior to immediate use. Expiration date is three (3) months from date of opening.

有效期

3 months
Contreras-Jurado, García-Serrano, Martínez-Fernández, Ruiz-Llorente, Paramio, Aranda: "Impaired hair growth and wound healing in mice lacking thyroid hormone receptors." in: PLoS ONE, Vol. 9, Issue 9, pp. e108137, (2015) (PubMed).

Mishra, Zhu, Ge, Cheng: "Adipogenesis is differentially impaired by thyroid hormone receptor mutant isoforms." in: Journal of molecular endocrinology, Vol. 44, Issue 4, pp. 247-55, (2010) (PubMed).
抗原

THRA (Thyroid Hormone Receptor, alpha (THRA))

别名

THRA (THRA 产品)

别名

AR7 antibody, CHNG6 antibody, EAR7 antibody, ERB-T-1 antibody, ERBA antibody, ERBA1 antibody, NR1A1 antibody, THRA1 antibody, THRA2 antibody, c-ERBA-1 antibody, C-ERBA-ALPHA antibody, TRalpha antibody, c-erba antibody, erba antibody, nr1a1-A antibody, thra-A antibody, thra1 antibody, TR[a]1 antibody, nr1a1 antibody, thra antibody, thral antibody, tra antibody, tra1 antibody, wu:fb59g07 antibody, Thra1 antibody, 6430529J03Rik antibody, AW259572 antibody, Erba antibody, Nr1a1 antibody, Rvr antibody, T3R[a] antibody, T3Ralpha antibody, Thra2 antibody, C-ERBA ALPHA1 antibody, Thra antibody, fTHRalphaA antibody, nr1a1-a antibody, thyroid hormone receptor, alpha antibody, thyroid hormone receptor, alpha L homeolog antibody, thyroid hormone receptor alpha a antibody, thyroid hormone receptor alpha antibody, thyroid hormone receptor alpha-A antibody, THRA antibody, thra.L antibody, thraa antibody, Thra antibody, tr-alpha antibody, LOC109641414 antibody

背景

This antibody is designed, produced, and is suitable for Cancer, Immunology and Nuclear Signaling research. Thyroid hormone receptor alpha is a nuclear hormone receptor with high affinity for the hormone triiodo-thyronine. THRA is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having a certain extent of redundancy, may mediate different functions of thyroid hormone. THRA interacts with NCOA3 and NCOA6 co-activators, leading to a strong increase in transcription of target genes. THRA is localized within the nucleus and has been found to exist as 4 isoforms originating from alternative splicing variants. Isoform 1 has a distinct C-terminus compared to isoform 2.
Synonyms: Thyroid hormone receptor alpha Nuclear receptor subfamily 1 group A member 1 c-erbA-alpha c-erbA-1 V-erbA-related protein 7 EAR-7

基因ID

7067, 40806160

途径

Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Sensory Perception of Sound, Cellular Response to Molecule of Bacterial Origin, Regulation of Lipid Metabolism by PPARalpha, Regulation of Muscle Cell Differentiation, Maintenance of Protein Location, Skeletal Muscle Fiber Development