THRA 抗体 (N-Term)
(2 references)
Quick Overview for THRA 抗体 (N-Term) (ABIN233838)
抗原
See all THRA 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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Supplier Product No.
- 600-401-a38
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Supplier
- Rockland
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原理
- THRA Antibody
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交叉反应 （详细）
- This antibody reacts with human THRA protein.
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产品特性
- Synonyms: rabbit anti-THRA antibody, rabbit anti-Thyroid hormone receptor alpha antibody, Nuclear receptor subfamily 1 group A member 1, c-erbA-alpha, c-erbA-1, V-erbA-related protein 7, EAR7, ERBA1, NR1A1, THRA1, THRA2
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纯化方法
- This product was affinity purified from monospecific antiserum by immunoaffinity chromatography.
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过滤
- Sterile filtered
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免疫原
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Immunogen: This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to a region near the amino terminus of human THRA isoform 1 protein.
Immunogen Type: Conjugated Peptide
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亚型
- IgG
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anti-Thyroid Hormone Receptor, alpha (THRA) (AA 87-178) antibody
THRA 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Thyroid Hormone Receptor, alpha (THRA) antibodyTHRA 适用: 人 WB, ELISA, IHC 宿主: 小鼠 Monoclonal H43 unconjugated
anti-Thyroid Hormone Receptor, alpha (THRA) antibody (HRP)THRA 适用: 人 WB, ELISA, IHC 宿主: 小鼠 Monoclonal H43 HRP
anti-Thyroid Hormone Receptor, alpha (THRA) antibody (FITC)THRA 适用: 人 WB, ELISA, IHC 宿主: 小鼠 Monoclonal H43 FITC
anti-Thyroid Hormone Receptor, alpha (THRA) antibody (Biotin)THRA 适用: 人 WB, ELISA, IHC 宿主: 小鼠 Monoclonal H43 Biotin
anti-Thyroid Hormone Receptor, alpha (THRA) antibody (PE)THRA 适用: 人 WB, ELISA, IHC 宿主: 小鼠 Monoclonal H43 PE
anti-Thyroid Hormone Receptor, alpha (THRA) antibody (PerCP)THRA 适用: 人 WB, ELISA, IHC 宿主: 小鼠 Monoclonal H43 PerCP
anti-Thyroid Hormone Receptor, alpha (THRA) antibody (APC)THRA 适用: 人 WB, ELISA, IHC 宿主: 小鼠 Monoclonal H43 APC
anti-Thyroid Hormone Receptor, alpha (THRA) antibody (Atto 488)THRA 适用: 人 WB, ELISA, IHC 宿主: 小鼠 Monoclonal H43 Atto 488
anti-Thyroid Hormone Receptor, alpha (THRA) antibody (Atto 594)THRA 适用: 人 WB, ELISA, IHC 宿主: 小鼠 Monoclonal H43 Atto 594
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应用备注
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Immunohistochemistry Dilution: 1:200
Application Note: This affinity purified antibody has been tested for use in ELISA and western blotting.
Western Blot Dilution: 1:500 - 1:2,000
Immunoprecipitation Dilution: 1:100
ELISA Dilution: 1:300,000
IF Microscopy Dilution: 1:200
Other: User Optimized
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.89 mg/mL
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缓冲液
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Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Stabilizer: None
Preservative: 0.01 % (w/v) Sodium Azide -
储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
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有效期
- 12 months
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: "Impaired hair growth and wound healing in mice lacking thyroid hormone receptors." in: PLoS ONE, Vol. 9, Issue 9, pp. e108137, (2015) (PubMed).
: "Adipogenesis is differentially impaired by thyroid hormone receptor mutant isoforms." in: Journal of molecular endocrinology, Vol. 44, Issue 4, pp. 247-55, (2010) (PubMed).
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: "Impaired hair growth and wound healing in mice lacking thyroid hormone receptors." in: PLoS ONE, Vol. 9, Issue 9, pp. e108137, (2015) (PubMed).
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- THRA (Thyroid Hormone Receptor, alpha (THRA))
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别名
- THRA
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背景
- Background: This antibody is designed, produced, and validated as part of a collaboration with the National Cancer Institute (NCI) and is suitable for Cancer, Immunology and Nuclear Signaling research. Thyroid hormone receptor alpha is a nuclear hormone receptor with high affinity for the hormone triiodo-thyronine. THRA is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having a certain extent of redundancy, may mediate different functions of thyroid hormone. THRA interacts with NCOA3 and NCOA6 co-activators, leading to a strong increase in transcription of target genes. THRA is localized within the nucleus and has been found to exist as 4 isoforms originating from alternative splicing variants. This antibody recognizes THRA isoform 1. Isoform 1 has a distinct C-terminus compared to isoform 2.
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基因ID
- 7067, 40806160
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UniProt
- P10827-2
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途径
- Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Sensory Perception of Sound, Cellular Response to Molecule of Bacterial Origin, Regulation of Lipid Metabolism by PPARalpha, Regulation of Muscle Cell Differentiation, Maintenance of Protein Location, Skeletal Muscle Fiber Development
抗原
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