(46 references)-
- 抗原
- Plasmacytoid Dendritic Cells
- 适用
- 小鼠
- 宿主
- 大鼠
- 克隆类型
- 单克隆
- 应用范围
- Functional Studies (Func)
- 特异性
- Mouse pDCs/Interferon producing cells (IPC) (extracellular domain)
- 免疫原
- mouse plasmatocytoid DCs (pDCs)
- 克隆位点
- 120G8-04
- 亚型
- IgG2a
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- 应用备注
- Flow Cytometry, in vivo depletion and IHC.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- 100 ug in 200ul PBS 50% glycerol
- 储存液
- Azide free
- 储存条件
- -20 °C
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: "Plasmacytoid dendritic cells in atherosclerosis: knocking at T-cell's door." in: Circulation, Vol. 130, Issue 16, pp. 1340-2, (2014) (PubMed).
: "Pivotal Functions of Plasmacytoid Dendritic Cells in Systemic Autoimmune Pathogenesis." in: Journal of clinical & cellular immunology, Vol. 5, Issue 2, pp. 212, (2014) (PubMed).
: "Type I IFN signaling in CD8- DCs impairs Th1-dependent malaria immunity." in: The Journal of clinical investigation, Vol. 124, Issue 6, pp. 2483-96, (2014) (PubMed).
: "Dendritic cells activated by double-stranded RNA induce arthritis via autocrine type I IFN signaling." in: Journal of leukocyte biology, Vol. 95, Issue 4, pp. 661-6, (2014) (PubMed).
: "Critical role of TLR7 signaling in the priming of cross-protective cytotoxic T lymphocyte responses by a whole inactivated influenza virus vaccine." in: PLoS ONE, Vol. 8, Issue 5, pp. e63163, (2013) (PubMed).
: "Modulation of respiratory dendritic cells during Klebsiella pneumonia infection." in: Respiratory research, Vol. 14, pp. 91, (2013) (PubMed).
: "In vivo ablation of plasmacytoid dendritic cells inhibits autoimmunity through expansion of myeloid-derived suppressor cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 190, Issue 6, pp. 2631-40, (2013) (PubMed).
: "Tumor promotion by intratumoral plasmacytoid dendritic cells is reversed by TLR7 ligand treatment." in: Cancer research, Vol. 73, Issue 15, pp. 4629-40, (2013) (PubMed).
: "Targeting antigen to bone marrow stromal cell-2 expressed by conventional and plasmacytoid dendritic cells elicits efficient antigen presentation." in: European journal of immunology, Vol. 43, Issue 3, pp. 595-605, (2013) (PubMed).
: "Convergent differentiation: myeloid and lymphoid pathways to murine plasmacytoid dendritic cells." in: Blood, Vol. 121, Issue 1, pp. 11-9, (2013) (PubMed).
: "The orchestrated functions of innate leukocytes and T cell subsets contribute to humoral immunity, virus control, and recovery from secondary poxvirus challenge." in: Journal of virology, Vol. 87, Issue 7, pp. 3852-61, (2013) (PubMed).
: "PAMPs and DAMPs in allergy exacerbation models." in: Methods in molecular biology (Clifton, N.J.), Vol. 1032, pp. 185-204, (2013) (PubMed).
: "Differential effect of CD69 targeting on bystander and antigen-specific T cell proliferation." in: Journal of leukocyte biology, Vol. 92, Issue 1, pp. 145-58, (2012) (PubMed).
: "Dendritic cells and regulatory T cells in atherosclerosis." in: Molecules and cells, Vol. 34, Issue 4, pp. 341-7, (2012) (PubMed).
: "Plasmacytoid dendritic cells play a role for effective innate immune responses during Chlamydia pneumoniae infection in mice." in: PLoS ONE, Vol. 7, Issue 10, pp. e48655, (2012) (PubMed).
: "Heterogeneity of respiratory dendritic cell subsets and lymphocyte populations in inbred mouse strains." in: Respiratory research, Vol. 13, pp. 94, (2012) (PubMed).
: "Immune insufficiency during GVHD is due to defective antigen presentation within dendritic cell subsets." in: Blood, Vol. 119, Issue 24, pp. 5918-30, (2012) (PubMed).
: "Plasmacytoid dendritic cells and their therapeutic activity in cancer." in: Oncoimmunology, Vol. 1, Issue 5, pp. 726-734, (2012) (PubMed).
: "Tissue-specific differentiation of a circulating CCR9- pDC-like common dendritic cell precursor." in: Blood, Vol. 119, Issue 25, pp. 6063-71, (2012) (PubMed).
: "Plasmacytoid dendritic cell depletion leads to an enhanced mononuclear phagocyte response in lungs of mice with lethal influenza virus infection." in: Comparative immunology, microbiology and infectious diseases, Vol. 35, Issue 4, pp. 309-17, (2012) (PubMed).
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: "Plasmacytoid dendritic cells in atherosclerosis: knocking at T-cell's door." in: Circulation, Vol. 130, Issue 16, pp. 1340-2, (2014) (PubMed).
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- 抗原
- Plasmacytoid Dendritic Cells
- 背景
- We generated rat monoclonal antibody (mAb) that recognizes mouse plasmacytoid dendritic cells (pDCs). This antibody, named 120G8, stains a small subset of CD11c(low) spleen cells with high specificity. This population produces high amounts of IFN-alpha upon in vitro viral stimulation. Both ex vivo- and in vitro-derived 120G8(+) cells display a phenotype identical with that of mouse pDCs (B220(high)Ly6C(high)Gr1(low)CD11b(-)CD11c(low)). Mice treated with 120G8 mAb are depleted of B220(high)Ly6C(high)CD11c(low) cells and have a much-reduced ability to produce IFN-alpha in response to in vivo CpG stimulation. MAb 120G8 stains all and only B220(high)Ly6C(high)CD11c(low) pDC in all lymphoid organs. Immunohistochemical studies performed with this mAb indicate that pDC are located in the T cell area of spleen, lymph nodes, and Peyer's patches. Using 120G8 mAb in immunofluorescence studies demonstrates mouse strain- and organ-specific differences in the frequency of pDCs and other DC subsets (Asselin-Paturel C et al., 2003 J. Immunol., 172:6466,Blasius AI, 2006,JImmunol,177:3260)
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