CHID1 抗体
(1 reference)Quick Overview for CHID1 抗体 (ABIN2192225)
抗原
See all CHID1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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过滤
- 0.2 μm filtered
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anti-Chitinase Domain Containing 1 (CHID1) (AA 20-393) antibody
CHID1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Chitinase Domain Containing 1 (CHID1) (AA 81-130) antibodyCHID1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Chitinase Domain Containing 1 (CHID1) (AA 1-393) antibodyCHID1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- The typical starting working dilution is 1:50. Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one
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限制
- 仅限研究用
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缓冲液
- PBS, containing 0.1 % bovine serum albumin and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.
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有效期
- 12 months
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: "Novel stabilin-1 interacting chitinase-like protein (SI-CLP) is up-regulated in alternatively activated macrophages and secreted via lysosomal pathway." in: Blood, Vol. 107, Issue 8, pp. 3221-8, (2006) (PubMed).
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: "Novel stabilin-1 interacting chitinase-like protein (SI-CLP) is up-regulated in alternatively activated macrophages and secreted via lysosomal pathway." in: Blood, Vol. 107, Issue 8, pp. 3221-8, (2006) (PubMed).
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- CHID1 (Chitinase Domain Containing 1 (CHID1))
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别名
- Stabilin-1 Interacting Chitinase-Like Protein
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背景
- The monoclonal antibody 1C11 recognizes human stabilin-1 interacting chitinase-like protein (SI-CLP). SI-CLP is a 39 kD member of the family of Glyco_18-domain-containing proteins. These chitinase-like proteins are involved primarily in Th2-associated disorders and tumor progression. Chitinase-like proteins are soluble mediators of cell differentiation, proliferation, activation, migration, and adherence. Chitinase like protein SI-CLP is a stabilin-1 interacting partner. SI-CLP gene expression was up- regulated by IL-4 and dexamethasone on the mRNA and protein levels in primary human macrophages in parallel with the expression of stabilin-1. The major site of SI-CLP intracellular localization is in Lamp1-positive and secretion commited CD63+ secretory lysosomes. The endocytic/sorting receptor stabilin-1 is a highly specific intracellular sorting receptor for SI-CLP. SI-CLP directly binds to, and colocalizes with stabilin-1. The lysosomal localization of SI-CLP in stabilin-1-negative macrophages, however, indicates that stabilin-1 may not be the only receptor mediating trafficking of newly synthesized SI-CLP. In vivo, the monoclonal antibody 1C11 recognizes SI-CLP in the cellular fraction of bronchoalveolar lavage specimens obtained from patients with chronic inflammatory disorders of the respiratory tract and in peripheral-blood leukocytes (PBLs) from these patients as well as healthy donors. Immunogen Amino acids 24 to 73 fragment GST-fusion protein Rat IgG2a
抗原
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