JAML 抗体
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北京 101111
Quick Overview for JAML 抗体 (ABIN2192220)
抗原
See all JAML (AMICA1) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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过滤
- 0.2 μm filtered
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anti-Adhesion Molecule, Interacts with CXADR Antigen 1 (AMICA1) (C-Term) antibody
AMICA1 适用: 人 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Adhesion Molecule, Interacts with CXADR Antigen 1 (AMICA1) (AA 1-355) antibodyAMICA1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Adhesion Molecule, Interacts with CXADR Antigen 1 (AMICA1) antibodyAMICA1 适用: 小鼠 FACS, IP 宿主: 仓鼠 Monoclonal 4E10 unconjugated
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应用备注
- It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50. Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one
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限制
- 仅限研究用
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缓冲液
- PBS, containing 0.1 % bovine serum albumin and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.
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有效期
- 12 months
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: "Unique role of junctional adhesion molecule-a in maintaining mucosal homeostasis in inflammatory bowel disease." in: Gastroenterology, Vol. 135, Issue 1, pp. 173-84, (2008) (PubMed).
: "Effects of culture conditions on heterogeneity and the apical junctional complex of the ARPE-19 cell line." in: Investigative ophthalmology & visual science, Vol. 47, Issue 8, pp. 3644-55, (2006) (PubMed).
: "The uremic solute p-cresol decreases leukocyte transendothelial migration in vitro." in: International immunology, Vol. 18, Issue 10, pp. 1453-9, (2006) (PubMed).
: "Interaction of junctional adhesion molecule with the tight junction components ZO-1, cingulin, and occludin." in: The Journal of biological chemistry, Vol. 275, Issue 27, pp. 20520-6, (2000) (PubMed).
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: "Unique role of junctional adhesion molecule-a in maintaining mucosal homeostasis in inflammatory bowel disease." in: Gastroenterology, Vol. 135, Issue 1, pp. 173-84, (2008) (PubMed).
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- JAML (AMICA1) (Adhesion Molecule, Interacts with CXADR Antigen 1 (AMICA1))
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别名
- Junctional Adhesion Molecule
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背景
- The monoclonal antibody BV16 recognizes the human junction adhesion molecule (JAM)-A. Together with JAM-C (JAM-2) and JAM-B (VE-JAM or JAM-3), JAM-A belongs to a family of adhesion proteins with a V-C2 immunoglobulin domain organization and their molecular weight is about 30-40 kDa. JAMs are important for a variety of cellular processes, including tight junction assembly, leukocyte transmigration, platelet activation, angiogenesis and virus binding. JAM-A is expressed by endothelial and epithelial cells, platelets, neutrophils, monocytes, lymphocytes and erythrocytes. Like all other JAMs, JAM-A plays an important role in tight junctions where it is involved in cell-to-cell adhesion through homophilic interaction. It codistributes with other tight junction components as ZO-1, 7H6 antigen, cingulin and occludin. JAM-A also plays an important role in leukocyte transmigration. Leukocyte transmigration can be blocked by antibodies and by soluble JAM-A/Fc fusion proteins. Homophilic JAM-A interactions between leukocytes and the endothelium but also heterophilic interactions of JAM-A with the beta2-integrin leukocyte function-associated antigen-1 (LFA-1) are considered to actively guide leukocytes during transmigration. Several studies imply a role for JAM-A in the initiation of atherosclerosis since JAM-A is upregulated on early atherosclerotic endothelium. The adhesion of activated platelets on the activated endothelium is mediated by homophilic interactions of JAM-A. PAM-1, JAM-1, JAMA, CD321, platelet F11 receptor Aliases Fusion protein consisting of the extracellular domain of human JAM and the Fc portion of human IgGs Immunogen Mouse IgG1
抗原
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