Secretory Leucocyte Protease Inhibitor 抗体
适用: 人
IA, IP, WB
宿主: 兔
Polyclonal
unconjugated
(1 reference)-
- 抗原
- Secretory Leucocyte Protease Inhibitor
- 适用
- 人
- 宿主
- 兔
- 克隆类型
- 多克隆
- 应用范围
- Immunoassay (IA), Immunoprecipitation (IP), Western Blotting (WB)
- 过滤
- 0.2 μm filtered
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- 应用备注
- For Western blotting dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:10.
- 限制
- 仅限研究用
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- 缓冲液
- PBS, containing 0.02 % sodium azide and 0.1 % bovine serum albumin.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 储存方法
- Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.
- 有效期
- 12 months
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: "Interactions among stimulated human polymorphonuclear leucocytes, released elastase and bronchial antileucoprotease." in: Clinical science (London, England : 1979), Vol. 75, Issue 1, pp. 53-62, (1988) (PubMed).
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: "Interactions among stimulated human polymorphonuclear leucocytes, released elastase and bronchial antileucoprotease." in: Clinical science (London, England : 1979), Vol. 75, Issue 1, pp. 53-62, (1988) (PubMed).
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- 抗原
- Secretory Leucocyte Protease Inhibitor
- 背景
- The antibody reacts with secretory leukocyte proteinase inhibitor (SLPI, also known as antileukoprotease (ALP)). SLPI is a 11.7 kDa cationic inhibitor of neutrophil elastase and to a lesser extent of cathepsin G. It is locally produced by epithelial cells in the lung, skin and other organs, by Polymorphonuclear leukocytes (PMN) and (in mice) by macrophages. In addition to its proteinase inhibitory properties that may serve to protect against proteolytic injury, it was recently shown that SLPI also displays several other functions such as antimicrobial and anti-inflammatory activities. These appear to be independent of its ability to inhibit PMN serine proteinases. SLPI has also been demonstrated to display antibacterial and antifungal activity at concentrations in which SLPI is present in mucosal secretions including those of the lung. Another possible role for SLPI is inhibition of protein-disulphide isomerase that is considered essential for invasion of a cell by the Human Immunodeficiency Virus (HIV).
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