(3 references)-
- 抗原 See all C6 抗体
- C6 (Complement Component 6 (C6))
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适用
- 大鼠
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This C6 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunoassay (IA)
- 过滤
- 0.2 μm filtered
- 克隆位点
- 3G11
- Top Product
- Discover our top product C6 Primary Antibody
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anti-Complement Component 6 (C6) (AA 682-934) antibody
C6 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Complement Component 6 (C6) (AA 30-58) antibodyC6 适用: 人 WB, IHC, ELISA, FACS, IF 宿主: 兔 Polyclonal unconjugated
anti-Complement Component 6 (C6) (AA 30-58), (N-Term) antibodyC6 适用: 人 WB, FACS, IF, IHC (p) 宿主: 兔 Polyclonal RB21849 unconjugated
anti-Complement Component 6 (C6) (C-Term) antibodyC6 适用: 人 IHC, ELISA, FACS, IHC (p) 宿主: 小鼠 Monoclonal 056B-214-2-4-2 unconjugated
anti-Complement Component 6 (C6) (Internal Region) antibodyC6 适用: 人, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- For immunohistology and Western blotting dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.
- 限制
- 仅限研究用
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- 缓冲液
- PBS, containing 0.1 % bovine serum albumin and 0.02 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 储存方法
- Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.
- 有效期
- 12 months
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: "The terminal sequence of complement plays an essential role in antibody-mediated renal cell apoptosis." in: Journal of the American Society of Nephrology : JASN, Vol. 10, Issue 6, pp. 1242-52, (1999) (PubMed).
: "Depletion of C6 prevents development of proteinuria in experimental membranous nephropathy in rats." in: The American journal of pathology, Vol. 135, Issue 1, pp. 185-94, (1989) (PubMed).
: "Increased urinary excretion of C5b-9 distinguishes passive Heymann nephritis in the rat." in: Kidney international, Vol. 35, Issue 1, pp. 60-8, (1989) (PubMed).
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: "The terminal sequence of complement plays an essential role in antibody-mediated renal cell apoptosis." in: Journal of the American Society of Nephrology : JASN, Vol. 10, Issue 6, pp. 1242-52, (1999) (PubMed).
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- 抗原
- C6 (Complement Component 6 (C6))
- Abstract
- C6 产品
- 别名
- zgc:64073 antibody, MGC82168 antibody, c6 antibody, MGC89471 antibody, C6 antibody, AW111623 antibody, complement component 6 antibody, complement C6 antibody, complement component 6, gene 1 L homeolog antibody, complement component 6, gene 2 antibody, c6 antibody, C6 antibody, c6.1.L antibody, c6.2 antibody
- 背景
- The monoclonal antibody 3G11 reacts specifically with rat C6. Proteolytic cleavage of C5 by C5 convertase generates C5b which initiates assembly of the C5b-9 membrane attack complex. Complement component C6 is part of this C5b-9 complex. This complex is assembled from five precursor molecules in the serum. The final step of C5b-9 complex formation involves polymerization of C9 which accompanies insertion of the complex into the cell membrane. The rat remnant kidney model had been widely used to identify mechanisms responsible for the progression of renal disease. Proteinuria is nephrotoxic and contributes to the progression of renal injury. Activation of complement in proteinuric urine results in tubular and interstitial damage. In C6- deficient rats, acute interstitial changes resolved despite ongoing proteinuria. This suggests that C6 mediates chronic progression of tubulointerstitial damage in rats with remnant kidneys. The monoclonal antibody 3G11 was raised by immunization of mice with C6 isolated from rat serum. Monoclonal antibody 3G11 can be used as detector in immuno assays detect C5b-9 in both serum and urine.
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