SFTPD 抗体
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北京 101111
Quick Overview for SFTPD 抗体 (ABIN2192111)
抗原
See all SFTPD 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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过滤
- 0.2 μm filtered
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anti-Surfactant Protein D (SFTPD) (AA 301-375) antibody
SFTPD 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC (p), IHC (fro), IF (p), IF (cc) 宿主: 兔 Polyclonal unconjugated
anti-Surfactant Protein D (SFTPD) (AA 259-374) antibodySFTPD 适用: 小鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Surfactant Protein D (SFTPD) (AA 292-321), (C-Term) antibodySFTPD 适用: 人, 大鼠 WB, IHC, ELISA, ICC 宿主: 兔 Polyclonal unconjugated
anti-Surfactant Protein D (SFTPD) (AA 21-375) antibodySFTPD 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Surfactant Protein D (SFTPD) (AA 21-375) antibodySFTPD 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 2C10 unconjugated
anti-Surfactant Protein D (SFTPD) antibodySFTPD 适用: Pig WB, IHC (p), IHC (fro), IF 宿主: 小鼠 Monoclonal 1-7 unconjugated
anti-Surfactant Protein D (SFTPD) (AA 21-375) antibodySFTPD 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 2A10 unconjugated
anti-Surfactant Protein D (SFTPD) (AA 45-221) antibodySFTPD 适用: 小鼠 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Surfactant Protein D (SFTPD) (AA 50-64) antibodySFTPD 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Surfactant Protein D (SFTPD) (AA 21-375) antibodySFTPD 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
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应用备注
- For immunohistology and Western blotting dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:10.
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限制
- 仅限研究用
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缓冲液
- PBS, containing 0.02 % sodium azide and 0.1 % bovine serum albumin.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.
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有效期
- 12 months
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: "Spatial and temporal expression of surfactant proteins in hyperoxia-induced neonatal rat lung injury." in: BMC pulmonary medicine, Vol. 6, pp. 8, (2006) (PubMed).
: "Monoclonal antibodies to surfactant protein D: evaluation of immunoreactivity in normal rat lung and in a radiation-induced fibrosis model." in: Experimental lung research, Vol. 21, Issue 4, pp. 577-88, (1995) (PubMed).
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: "Spatial and temporal expression of surfactant proteins in hyperoxia-induced neonatal rat lung injury." in: BMC pulmonary medicine, Vol. 6, pp. 8, (2006) (PubMed).
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- SFTPD (Surfactant Protein D (SFTPD))
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别名
- Surfactant Protein D
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背景
- The monoclonal antibody IIIH3 recognizes the rat surfactant protein D (SP-D). SP-D belongs to the collectin familiy. These proteins are oligomeric proteins composed of carbohydrate-recognition domains (CRD) attached to collagenous regions. They are structurally similar to the ficolins although they make use of different CRD structures: C-type lectin domain for the collectins. The anti-microbial effector mechanisms of SP-D are direct opsonization, neutralization, and agglutination. Thus limiting the infection and concurrently orchestrating the subsequent adaptive immune response. The lung is the major site of synthesis of SP-D, where the molecules are produced and secreted onto the epithelial surface by alveolar type II cells and unciliated bronchial epithelial cells. SP-D is also found in different epithelial cells of the gastrointeststinal tract and in epithelial cells of exocrine glands. SP-D synthesis and secretion increase significantly after inflammatory stress. Increased amounts of SP-D in lavage and tissue, particularly in type II pneumocytes, in Clara cells and in hyperplastic goblet cells are found in inflamed lungs. The localization of SP-D in endocytic vesicles and in lysosomal granules of alveolar macrophages suggests that a receptor-mediated uptake occurs. SP-D binds to apoptotic neutrophils and enhances their clearance by alveolar macrophages. Monoclonal antibody IIIH3 specific for rat surfactant protein D shows significant cross reactivity with human SP-D.
抗原
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