CD96 抗体
Quick Overview for CD96 抗体 (ABIN2192060)
抗原
See all CD96 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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过滤
- 0.2 μm filtered
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应用备注
- For flow cytometry dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50. For functional studies in vitro dilutions have to be made according to the amounts of CD96 to be inactivated.
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限制
- 仅限研究用
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缓冲液
- PBS, containing 0.1 % bovine serum albumin.
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储存条件
- 4 °C
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储存方法
- Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.
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有效期
- 12 months
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Cutting edge: CD96 (tactile) promotes NK cell-target cell adhesion by interacting with the poliovirus receptor (CD155)." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 172, Issue 7, pp. 3994-8, (2004) (PubMed).
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Cutting edge: CD96 (tactile) promotes NK cell-target cell adhesion by interacting with the poliovirus receptor (CD155)." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 172, Issue 7, pp. 3994-8, (2004) (PubMed).
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- CD96
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别名
- CD96
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背景
- The monoclonal antibody NK92.39 reacts with CD96, also known as T cell-Activated Increased Late Expression (Tactile). CD96 promotes natural killer (NK) cell adhesion to target cells expressing the poliovirus receptor (PVR/CD155). Furthermore, CD96 stimulates cytotoxicity of activated NK cells, and mediates acquisition of PVR from target cells. NK cells have due to the receptor CD96 a dual receptor system that recognizes nectins and nectin-like molecules on target cells. This mediates NK cell adhesion and triggering of effector functions. As PVR is highly expressed in certain tumors, this receptor system may be critical for NK cell recognition of tumors. The monoclonal antibody NK92.39 blocks binding of soluble poliovirus receptor (PVR) to NK92 cells.
抗原
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