MARCO 抗体
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北京 101111
Quick Overview for MARCO 抗体 (ABIN2192057)
抗原
See all MARCO 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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交叉反应 （详细）
- Cross reactivity: Bovine : Yes, Chicken : No
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过滤
- 0.2 μm filtered
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亚型
- IgG3
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anti-Macrophage Receptor with Collagenous Structure (MARCO) (AA 367-519) antibody
MARCO 适用: 大鼠 WB, IP, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-Macrophage Receptor with Collagenous Structure (MARCO) (AA 421-520) antibodyMARCO 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Macrophage Receptor with Collagenous Structure (MARCO) (AA 13-40) antibodyMARCO 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB24662 unconjugated
anti-Macrophage Receptor with Collagenous Structure (MARCO) (AA 366-518) antibodyMARCO 适用: 小鼠 WB, IP, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-Macrophage Receptor with Collagenous Structure (MARCO) (AA 370-419) antibodyMARCO 适用: 人, 小鼠, 马 WB 宿主: 兔 Polyclonal unconjugated
anti-Macrophage Receptor with Collagenous Structure (MARCO) (AA 71-120) antibodyMARCO 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Macrophage Receptor with Collagenous Structure (MARCO) antibodyMARCO 适用: 人 WB, IP, FACS, IF, IHC (fro) 宿主: 兔 Chimeric PLK1 unconjugated Recombinant Antibody
anti-Macrophage Receptor with Collagenous Structure (MARCO) (N-Term) antibodyMARCO 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Macrophage Receptor with Collagenous Structure (MARCO) (C-Term) antibodyMARCO 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Macrophage Receptor with Collagenous Structure (MARCO) (N-Term) antibodyMARCO 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- For immunohistochemistry and flow cytometry, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50. For functional studies, in vitro dilutions have to be optimized in user's experimental setting. Positive Human alveolar macrophages control Negative All other human cells control
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限制
- 仅限研究用
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缓冲液
- PBS, containing 0.1 % bovine serum albumin.
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储存条件
- 4 °C
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储存方法
- Product should be stored at 4 °C. Under recommended storage conditions, product is stable for at least one year. The exact expiry date is indicated on the label.
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: "MARCO is the major binding receptor for unopsonized particles and bacteria on human alveolar macrophages." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 175, Issue 9, pp. 6058-64, (2005) (PubMed).
: "MARCO expression on pediatric alveolar macrophages." in: Cytometry. Part B, Clinical cytometry, Vol. 60, Issue 1, pp. 54-6, (2004) (PubMed).
: "Receptors for unopsonized particles: the role of alveolar macrophage scavenger receptors." in: Current molecular medicine, Vol. 1, Issue 5, pp. 589-95, (2002) (PubMed).
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: "MARCO is the major binding receptor for unopsonized particles and bacteria on human alveolar macrophages." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 175, Issue 9, pp. 6058-64, (2005) (PubMed).
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- MARCO (Macrophage Receptor with Collagenous Structure (MARCO))
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别名
- Marco
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背景
- The monoclonal antibody PLK-1 recognizes the macrophage receptor with collagenous structure (MARCO). The scavenger receptors (SRs) expressed by macrophages are thought to play an important role in the immune response against bacteria by mediating ligand binding and phagocytosis. SRs can be divided into three different classes based upon their structural properties, which are termed SR-A, SR-B and SR-C. SRs-A are homotrimeric glycoproteins composed of 77 kDa monomers subdivided into 3 types.. The molecular structure of MARCO resembles that of SR-A type I, containing a triple-helical collagenous domain and a scavenger receptor cysteine-rich (SRCR) domain at the C terminus. MARCO is only expressed in some subpopulations of macrophages, although it's expression can be strongly upregulated during infection or LPS treatment. Furthermore, MARCO is, like sinusoidal endothelial cell markers DC-SIGNR, LYVE-1 and stabilin-2, expressed by sinusoidal endothelial cells in lymph node. MARCO expressed by alveolar macrophages seems to play an important role in response to inhaled particles and airborne pathogens. The monoclonal antibody PLK-1 binds specifically to MARCO, and has been shown to partially block ligand binding. Aliases SCARA2, scavenger receptor class A member 2, macrophage receptor with collagenous structure Immunogen Human alveolar macrophages (recognizes domain V between residues 420 and 431)
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途径
- Activation of Innate immune Response
抗原
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