Transferrin Receptor 抗体
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北京 101111
Quick Overview for Transferrin Receptor 抗体 (ABIN2192003)
抗原
See all Transferrin Receptor (TFRC) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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过滤
- 0.2 μm filtered
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应用备注
- For Western blotting, flow cytometry and immunohistology dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:10.
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限制
- 仅限研究用
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缓冲液
- PBS, containing 0.02 % sodium azide and 0.1 % bovine serum albumin.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.
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有效期
- 12 months
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: "Heterotypic interactions between transferrin receptor and transferrin receptor 2." in: Blood, Vol. 101, Issue 5, pp. 2008-14, (2003) (PubMed).
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: "Heterotypic interactions between transferrin receptor and transferrin receptor 2." in: Blood, Vol. 101, Issue 5, pp. 2008-14, (2003) (PubMed).
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- Transferrin Receptor (TFRC) (Transferrin Receptor (p90, CD71) (TFRC))
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背景
- Human transferrin receptor 1 (TfR1), also designated CD71, is a homodimeric type II membrane glycoprotein of 90-95 kDa. This receptor binds two molecules of the serum iron-transport protein transferrin (Tf) and is internalised into endosomes that are acidified, resulting in the release of iron from Tf. TfR1 is not expressed on resting leukocytes but is upregulated on all proliferating cells upon activation, reflecting the iron dependence of proliferation. In tissues TfR1 is expressed on most dividing cells and on brain capillary endothelium. Expression of TfR1 is down regulated as a result of iron overload. TfR1 shares 45 % identity with TfR2.
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途径
- Transition Metal Ion Homeostasis
抗原
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