(4 references)-
- 抗原 See all F11R 抗体
- F11R (F11 Receptor (F11R))
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This F11R antibody is un-conjugated
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应用范围
- Western Blotting (WB), Flow Cytometry (FACS), Functional Studies (Func)
- 过滤
- 0.2 μm filtered
- 克隆位点
- M-Ab-F11
- Top Product
- Discover our top product F11R Primary Antibody
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anti-F11 Receptor (F11R) (AA 1-299) antibody
F11R 适用: 人 WB, ELISA, IHC (p), PLA 宿主: 小鼠 Monoclonal 2E3-1C8 unconjugated
anti-F11 Receptor (F11R) (AA 30-238) antibodyF11R 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-F11 Receptor (F11R) (AA 1-299) antibodyF11R 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-F11 Receptor (F11R) (Internal Region) antibodyF11R 适用: 人, 大鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-F11 Receptor (F11R) (AA 64-249) antibodyF11R 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-F11 Receptor (F11R) antibodyF11R 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-F11 Receptor (F11R) (AA 31-224) antibodyF11R 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-F11 Receptor (F11R) (AA 1-299) antibodyF11R 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-F11 Receptor (F11R) (C-Term) antibodyF11R 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-F11 Receptor (F11R) (N-Term) antibodyF11R 适用: 人 WB, IHC (p) 宿主: 兔 Monoclonal RM275 unconjugated
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- 应用备注
- For immunohistochemistry, flow cytometry and Western blotting, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50. For functional studies, dilutions have to be optimized in user's experimental setting.
- 限制
- 仅限研究用
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- 缓冲液
- PBS, containing 0.1 % bovine serum albumin.
- 储存条件
- 4 °C
- 储存方法
- Product should be stored at 4 °C. Under recommended storage conditions, product is stable for at least one year. The exact expiry date is indicated on the label.
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: "Two regions of the human platelet F11-receptor (F11R) are critical for platelet aggregation, potentiation and adhesion." in: Thrombosis and haemostasis, Vol. 87, Issue 4, pp. 712-21, (2002) (PubMed).
: "Mechanisms of platelet activation by a stimulatory antibody: cross-linking of a novel platelet receptor for monoclonal antibody F11 with the Fc gamma RII receptor." in: The Biochemical journal, Vol. 310 ( Pt 1), pp. 155-62, (1995) (PubMed).
: "Stimulatory antibody-induced activation and selective translocation of protein kinase C isoenzymes in human platelets." in: The Biochemical journal, Vol. 311 ( Pt 2), pp. 401-6, (1995) (PubMed).
: "Activation of human platelets by a stimulatory monoclonal antibody." in: The Journal of biological chemistry, Vol. 265, Issue 17, pp. 10042-8, (1990) (PubMed).
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: "Two regions of the human platelet F11-receptor (F11R) are critical for platelet aggregation, potentiation and adhesion." in: Thrombosis and haemostasis, Vol. 87, Issue 4, pp. 712-21, (2002) (PubMed).
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- 抗原
- F11R (F11 Receptor (F11R))
- 别名
- Junctional Adhesion Molecule-A (F11R 产品)
- 别名
- CD321 antibody, JAM antibody, JAM1 antibody, JAMA antibody, JCAM antibody, KAT antibody, PAM-1 antibody, 9130004G24 antibody, AA638916 antibody, ESTM33 antibody, JAM-1 antibody, JAM-A antibody, Jcam antibody, Jcam1 antibody, Ly106 antibody, Jam1 antibody, F11 receptor antibody, F11R antibody, F11r antibody
- 背景
- The monoclonal antibody M.Ab.F11 recognizes junctional adhesion molecule-A (JAM-A) also known as the human platelet F11-Receptor (F11R) or JAM-1. JAM-A is a surface glycoprotein duplex (32 and 35 kDa) belongingto the immunoglobulin superfamily found on the surface of human platelets and at intercellular junctions of endothelial cells and epithelial cells. JAM-A belongs together with JAM-C (JAM-2) and JAM-B (VE-JAM or JAM-3) to a family of adhesion proteins with a V-C2 immunoglobulin domain organization. JAM-A plays an important role in tight junctions where it is involved in cell-to-cell adhesion through homophilic interactions. It co-distributes with other tight junction components such as ZO-1, 7H6 antigen, cingulin and occludin. Moreover, JAM-A plays a role in platelet aggregation, secretion, adhesion, spreading. In the platelet, JAM-A is a membrane protein involved in 2 distinct processes initiated on the platelet surface. Namely, antibody-induced platelet aggregation and secretion both dependent on FcgammaRII and GPIIb/IIIa integrin, a process that may be involved in pathophysiological processes associated with certain thrombocytopenias and secondly, antibody mediated platelet adhesion independent from FcgammaRII or fibrinogen receptor that appears to play a role in physiological processes associated with platelet adhesion and aggregation. A physiological role for the JAM-A protein was demonstrated by its phosphorylation after the stimulation of platelets by thrombin and collagen. A pathophysiological role for the JAM-A was revealed by demonstrating the presence of JAM-A antibodies in patients with thrombocytopenia. Adhesion of platelets through JAM-A resulted in events characteristic of the action of cell adhesion molecules. Recent data suggests a role for JAM-A in the adhesion of platelets to cytokine-inflamed endothelial cells and thus in thrombosis and atherosclerosis induced in non-denuded blood vessels by inflammatory processes. Aliases JAM-1, platelet F11 receptor, F11R, platelet adhesion molecule, CD321 Immunogen Human platelet membranes
- 途径
- Cell-Cell Junction Organization
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