C1QBP 抗体
(4 references)-
- 抗原 See all C1QBP 抗体
- C1QBP (Complement Component 1, Q Subcomponent Binding Protein (C1QBP))
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This C1QBP antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (IF), Flow Cytometry (FACS), Functional Studies (Func), Immunoassay (IA)
- 交叉反应 （详细）
- Cross reactivity: Rat : Yes
- 过滤
- 0.2 μm filtered
- 克隆位点
- 74-5-2
- 亚型
- IgG1
- Top Product
- Discover our top product C1QBP Primary Antibody
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anti-Complement Component 1, Q Subcomponent Binding Protein (C1QBP) (AA 76-282) antibody
C1QBP 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Complement Component 1, Q Subcomponent Binding Protein (C1QBP) (AA 76-282) antibodyC1QBP 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C3 unconjugated
anti-Complement Component 1, Q Subcomponent Binding Protein (C1QBP) (AA 71-278) antibodyC1QBP 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Complement Component 1, Q Subcomponent Binding Protein (C1QBP) (AA 1-282) antibodyC1QBP 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Complement Component 1, Q Subcomponent Binding Protein (C1QBP) (AA 74-282) antibodyC1QBP 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Complement Component 1, Q Subcomponent Binding Protein (C1QBP) (AA 71-278) antibodyC1QBP 适用: Cow WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Complement Component 1, Q Subcomponent Binding Protein (C1QBP) (Internal Region) antibodyC1QBP 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Complement Component 1, Q Subcomponent Binding Protein (C1QBP) (AA 190-282) antibodyC1QBP 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Complement Component 1, Q Subcomponent Binding Protein (C1QBP) (AA 173-282) antibodyC1QBP 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Complement Component 1, Q Subcomponent Binding Protein (C1QBP) antibodyC1QBP 适用: 人, 小鼠, 大鼠 WB, IF 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- For flow cytometry and Western blotting, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50. For functional studies, in vitro dilutions have to be optimized in user's experimental setting. Website:
- 限制
- 仅限研究用
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- 缓冲液
- PBS, containing 0.1 % bovine serum albumin.
- 储存条件
- 4 °C
- 储存方法
- Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.
- 有效期
- 12 months
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: "Role of the receptor for the globular domain of C1q protein in the pathogenesis of hepatitis C virus-related cryoglobulin vascular damage." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 183, Issue 9, pp. 6013-20, (2009) (PubMed).
: "gC1qR/p33 blockade reduces Staphylococcus aureus colonization of target tissues in an animal model of infective endocarditis." in: Infection and immunity, Vol. 74, Issue 8, pp. 4418-23, (2006) (PubMed).
: "gC1q-R/p33, a member of a new class of multifunctional and multicompartmental cellular proteins, is involved in inflammation and infection." in: Immunological reviews, Vol. 180, pp. 65-77, (2001) (PubMed).
: "Identification of functional domains on gC1Q-R, a cell surface protein that binds to the globular "heads" of C1Q, using monoclonal antibodies and synthetic peptides." in: Hybridoma, Vol. 15, Issue 5, pp. 333-42, (1997) (PubMed).
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: "Role of the receptor for the globular domain of C1q protein in the pathogenesis of hepatitis C virus-related cryoglobulin vascular damage." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 183, Issue 9, pp. 6013-20, (2009) (PubMed).
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- 抗原
- C1QBP (Complement Component 1, Q Subcomponent Binding Protein (C1QBP))
- Abstract
- C1QBP 产品
- 别名
- SF2 antibody, X38k antibody, gC1qR antibody, C1QBP antibody, GC1QBP antibody, HABP1 antibody, SF2p32 antibody, gC1Q-R antibody, p32 antibody, AA407365 antibody, AA986492 antibody, D11Wsu182e antibody, P32 antibody, gC1qBP antibody, Habp1 antibody, complement C1q binding protein antibody, complement component 1, q subcomponent binding protein S homeolog antibody, complement component 1, q subcomponent binding protein antibody, C1QBP antibody, c1qbp.S antibody, LOC100227158 antibody, C1qbp antibody
- 背景
- The monoclonal antibody 74.5.2 recognizes a cell membrane C1q binding molecule that recognises the globular heads of C1q. It is also present in plasma and the extracellular matrix. The molecule is an unusually acidic, single chain protein with an apparent molecular weight of 33 kDa. It does not possess a conventional sequence motif compatible with a membrane spanning segment nor a consensus site for a GPI anchor. gC1qR migrates as a single chain under both reducing and non-reducing conditions, but it behaves as an oligomer on gel-filtration in non-dissociating conditions. Its multimer formation may be a critical process by which the gC1qR molecule increases its affinity for multivalent ligands such as C1q. gC1qR has been shown to inhibit complement activation by preventing the binding of C1q to antibodies, suggesting that the binding site for gC1qR and the binding site for immune complexes, which are present on the C1q globular 'heads', may be located at the same position. gC1qR is capable of interacting with several proteins involved in blood clotting, namely, thrombin, prothrombin, the heparinbinding form of vitronectin, the ternary complex, vitronectin-thrombin-antithrombin, as well as high-molecular-weight kininogen and Hageman factor. Besides its role in the complement pathway, gC1qR participates in enhancement of Fc-receptor and CR1-mediated phagocytosis, procoagulant activity on platelets, and chemotactic activity on mast cells, eosinophils, neutrophils, and fibroblasts. gC1qR is expressed on a wide variety of cells and can serve as a binding site for plasma and microbial proteins. Its antigenic sites may be cryptic on cells in suspension but become exposed when the cells are fixed by bifunctional cross-linkers. Probably it is also expressed on the cell membrane as a tetramer. Crosslinking or activation may thus bring about a tetrameric assembly of gC1qR followed by a conformational change within the molecule, thereby exposing epitopes which are otherwise hidden. A form of gC1qR is also found inside the cell. Intracellular gC1qR has been shown to bind the cytoplasmic tail of the α1B-adrenergic receptor and to PKCμ. The monoclonal antibody 74.5.2 is directed against epitopes in the XC15 peptide that contains a binding site for high-molecular-weight kininogen and Factor XII.
- 途径
- Ribonucleoprotein Complex Subunit Organization, Ribosome Assembly
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