MHC, Class I 抗体
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北京 101111
Quick Overview for MHC, Class I 抗体 (ABIN2191839)
抗原
See all MHC, Class I 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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过滤
- 0.2 μm filtered
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anti-MHC, Class I antibody
适用: 人, 大鼠 WB, IHC, IF, ELISA, ICC 宿主: 兔 Polyclonal unconjugated
anti-MHC, Class I antibodyKD Validated 适用: 人 FACS, WB 宿主: 兔 Monoclonal 24GB6040 unconjugated Recombinant Antibody
anti-MHC, Class I antibody适用: 绵羊, Cat FACS, WB, IP, IHC (fro) 宿主: 小鼠 Monoclonal VPM19 unconjugated
anti-MHC, Class I antibody适用: 小鼠 IHC, IP, IA 宿主: 兔 Chimeric R1-21-2 unconjugated Recombinant Antibody
anti-MHC, Class I (AA 81-180) antibody适用: 人 WB, ELISA, IHC (fro), ICC, IF (cc), IF (p), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-MHC, Class I antibody适用: 小鼠 IP, IF, IA 宿主: 兔 Chimeric R1-9-6 unconjugated Recombinant Antibody
anti-MHC, Class I antibody (PE)适用: 小鸡 FACS, IHC 宿主: 小鼠 Monoclonal F21-2 PE
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应用备注
- For immunohistology and flow cytometry, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.
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限制
- 仅限研究用
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缓冲液
- PBS, containing 0.1 % bovine serum albumin and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Product should be stored at 4 °C. Under recommended storage conditions, product is stable for one year.
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有效期
- 12 months
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- MHC, Class I
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别名
- Mhc Class I
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背景
- The monoclonal antibody ER-HR52 specifically reacts with major histocompatibility complex (MHC) class I antigens of the mouse and, therefore, it is a valuable tool for studying cytotoxic T-cell interactions with class I positive antigen presenting cells. The primary immunological function of MHC molecules is to bind and present antigenic peptides on the surfaces of cells for recognition by the antigen-specific T cell receptors (TCRs) of lymphocytes. MHC class I molecules are expressed on the surfaces of most cells and are recognized by CD8-positive cytotoxic T-cells, an essential step for initiating the elimination of virally infected cells by T-cell-mediated lysis. MHC class I molecules are heterodimers composed of an alpha (44kD) and a beta (beta microglobulin, 11 kD) subunit. The first two structural domains of the alpha subunit associate to form the peptide-binding pocket. The monoclonal antibody ER-HR52 reacts with MHC class I, an antigen that is expressed by all somatic cells at varying levels. Lymphocytes are highly positive, whereas fibroblasts and neurons show only a low level of antigen expression. ER-HR52 recognizes murine MHC class I molecules on the surface of cells of the following haplotypes: H-2Db, H-2Dw16, H-2d,p,q. Weaker reactivity is found in mice of the following haplotypes: H-2f,r,s,w17, w23,w27. MHC class I molecules of other haplotypes are not recognized by ER-MP52. There is no cross-reactivity with human MHC class I molecules.
抗原
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