(4 references)-
- 抗原 See all Myeloperoxidase (MPO) 抗体
- Myeloperoxidase (MPO)
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适用
- 小鼠
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This Myeloperoxidase antibody is conjugated to FITC
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应用范围
- Immunoassay (IA)
- 交叉反应 （详细）
- Cross reactivity: Rat MPO : Yes
- 过滤
- 0.2 μm filtered
- 克隆位点
- 8F4
- 亚型
- IgG1
- Top Product
- Discover our top product MPO Primary Antibody
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anti-Myeloperoxidase (MPO) antibody
MPO 适用: 人 WB, IF 宿主: 兔 Monoclonal unconjugated
anti-Myeloperoxidase (MPO) (AA 134-263) antibodyMPO 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Myeloperoxidase (MPO) antibodyMPO 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Myeloperoxidase (MPO) (AA 646-745) antibodyMPO 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3E11 unconjugated
anti-Myeloperoxidase (MPO) (AA 50-310) antibodyMPO 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Myeloperoxidase (MPO) (AA 406-745) antibodyMPO 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Myeloperoxidase (MPO) (AA 678-745) antibodyMPO 适用: 人, 小鼠, 大鼠 ELISA, FACS, ICC, IHC (p), IHC (fro), IF (p), IF (cc) 宿主: 兔 Polyclonal unconjugated
anti-Myeloperoxidase (MPO) (AA 253-718) antibodyMPO 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Myeloperoxidase (MPO) (C-Term) antibodyMPO 适用: 人, 小鼠, 大鼠, 兔 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Myeloperoxidase (MPO) antibodyMPO 适用: 人 IHC 宿主: 小鼠 Monoclonal MSVA-692M unconjugated
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- 应用备注
- For immunohistochemistry and flow cytometry, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50 Positive Neutrophils isolated from digested infarcts control 1
- 限制
- 仅限研究用
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- 缓冲液
- PBS, containing 1 % bovine serum albumin and 0.02 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 储存方法
- Product should be stored at 4 °C. Under recommended storage conditions, product is stable for at least one year. The exact expiry date is indicated on the label.
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: "Myeloperoxidase is critically involved in the induction of organ damage after renal ischemia reperfusion." in: The American journal of pathology, Vol. 171, Issue 6, pp. 1743-52, (2007) (PubMed).
: "Accumulation of myeloperoxidase-positive neutrophils in atherosclerotic lesions in LDLR-/- mice." in: Arteriosclerosis, thrombosis, and vascular biology, Vol. 28, Issue 1, pp. 84-9, (2007) (PubMed).
: "C/EBPalpha directs monocytic commitment of primary myeloid progenitors." in: Blood, Vol. 108, Issue 4, pp. 1223-9, (2006) (PubMed).
: "Aggravation of anti-myeloperoxidase antibody-induced glomerulonephritis by bacterial lipopolysaccharide: role of tumor necrosis factor-alpha." in: The American journal of pathology, Vol. 167, Issue 1, pp. 47-58, (2005) (PubMed).
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: "Myeloperoxidase is critically involved in the induction of organ damage after renal ischemia reperfusion." in: The American journal of pathology, Vol. 171, Issue 6, pp. 1743-52, (2007) (PubMed).
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- 抗原
- Myeloperoxidase (MPO)
- 别名
- Myeloperoxidase (MPO 产品)
- 别名
- mKIAA4033 antibody, MPO antibody, LOC100335032 antibody, POX2' antibody, XPOX2' antibody, mpo antibody, mpo-A antibody, pmr-1 antibody, pmr1 antibody, pox2 antibody, xpox2 antibody, myeloperoxidase antibody, myeloperoxidase L homeolog antibody, MPO antibody, Mpo antibody, LOC100335032 antibody, mpo.L antibody
- 背景
- The monoclonal antibody 8F4 recognizes mouse myeloperoxidase (MPO). MPO is a glycoprotein produced as a single precursor, which is subsequently cleaved into a alpha and beta chain. In human the biologically active MPO is a 150 kDa tetramer composed of 2 glycosylated alfa chains of 59-64 kDa and 2 beta chains of 14 kDa. MPO is stored in azurophilic granules of polymorphonuclear leukocytes and is rapidly released into the phagosome and extracellular space during inflammatory conditions.The enzyme catalyzes the conversion of chloride and hydrogen peroxide to hypochlorite, a potent oxidant, which functions in host defense against microorganisms. Involvement of MPO has been described in several human diseases, such as cardiovascular disease, airway inflammation, lung cancer, Alzheimer's disease and multiple sclerosis. A positive correlation between elevated MPO levels in serum and cardiovascular disease suggest an interesting role for MPO as an diagnostic marker, making it possible to identify patients at risk for future cardiac events. Furthermore, there are some autoimmune diseases, in which MPO is targeted by antineutrophil cytoplasm antibodies. Studies with MPO-knockout mice have shown an increased susceptibility to pneumonia following intratracheal infections. Moreover, MPO deficient mice are more susceptible to experimental autoimmune encephalitis, a T cell-dependent neuronal disease, and have an increased expression of arteriosclerotic plaques compared to wild-type mice. The anti-mouse MPO monoclonal antibody 8F4 recognizes natural MPO in biological solutions by ELISA, in frozen tissue sections fixed with acetone and in flow cytometry using a cell permeabilization method. The antibody 8F4 is cross-reactive with rat MPO. Immunogen Purified mouse MPO from WEHI-3 cells
- 途径
- Chromatin Binding
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