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Transferrin Receptor 抗体

TFRC 适用: 大鼠 FACS, WB, IHC, IHC (fro) 宿主: 小鼠 Monoclonal OX-26 unconjugated
产品编号 ABIN217649
发货至: 中国
  • 抗原 See all Transferrin Receptor (TFRC) 抗体
    Transferrin Receptor (TFRC) (Transferrin Receptor (p90, CD71) (TFRC))
    适用
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    大鼠
    宿主
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    小鼠
    克隆类型
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    单克隆
    标记
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    This Transferrin Receptor antibody is un-conjugated
    应用范围
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    Flow Cytometry (FACS), Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Frozen Sections) (IHC (fro))
    特异性
    Recognizes rat CD71, also known as transferrin receptor, a homodimeric type II transmembrane protein, expressed by all proliferating cells and cells with a requirement for iron, including reticulocytes and capillary endothelium in brain. Clone 0X-26 also binds to a number of non-dividing normal tissues. The balance between a sufficient amount of iron uptake and prevention of accumulation of excess iron within a cell, is vitally important to maintain cellular functions such as oxygen and electron transport and mitochondrial energy metabolism, whilst preventing permanent cell and tissue damage. Transferrin receptor (CD71), transferrin and ferritin have been identified as specialized proteins which control the uptake, transport and storage of free iron in tissues, thereby maintaining iron homeostasis. An imbalance in iron homeostasis within the brain has been linked with the neurodegenerative diseases, Alzheimer's€™s, Parkinson's, Huntington's and Multiple Sclerosis. Is reported as suitable for use in immunoelectron microscopy. OX-26 detects a band of ~95kD in Western blotting under reducing conditions and ~195kD under non-reducing conditions reflecting it's homodimeric structure.
    纯化方法
    Protein G purified
    内毒素水平
    Low Endotoxin
    免疫原
    PHA activated rat lymphocytes.

    Type of Immunogen: Cells
    克隆位点
    OX-26
    亚型
    IgG2a
    Top Product
    Discover our top product TFRC Primary Antibody
  • 应用备注
    Approved: Flo (1:10 - 1:100), IHC, IHC-Fr, WB

    Usage: The applications listed have been tested for the unmodified form of this product. Other forms have not been tested. Flow Cytometry: Use 10 μL of the suggested working dilution to label 10^6 cells in 100 μL. Method sheets are available on request.
    说明

    Target Species of Antibody: Rat

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    Lot specific
    缓冲液
    PBS.
    注意事项
    Aliquot to Avoid freeze/thaw cycles. Store undiluted.
    储存条件
    -20 °C
    储存方法
    Store at -20°C. Aliquot to avoid freeze-thaw cycles. Store undiluted.
  • 抗原
    Transferrin Receptor (TFRC) (Transferrin Receptor (p90, CD71) (TFRC))
    别名
    CD71 / Transferrin Receptor (TFRC 产品)
    背景
    Name/Gene ID: TFRC
    Subfamily: Metallopeptidase M28B
    Family: Protease

    Synonyms: TFRC, CD71, TFR1, TRFR, TFR, TR, CD71 antigen, p90, T9, Transferrin receptor, Transferrin receptor protein 1
    基因ID
    7037
    途径
    Transition Metal Ion Homeostasis
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