GPR161 抗体 (AA 121-220)
Quick Overview for GPR161 抗体 (AA 121-220) (ABIN2174751)
抗原
See all GPR161 抗体适用
宿主
克隆类型
标记
应用范围
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    - 
                                            抗原表位
- AA 121-220
- 
                                            交叉反应
- 人
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                                            预测反应
- Mouse,Rat,Dog,Cow,Sheep,Pig,Horse
- 
                                            纯化方法
- Purified by Protein A.
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                                            免疫原
- KLH conjugated synthetic peptide derived from human GPR161
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                                            亚型
- IgG
 
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                                            应用备注
- 
                        WB 1:300-5000
 ELISA 1:500-1000
 IHC-P 1:200-400
 IHC-F 1:100-500
 IF(IHC-P) 1:50-200
 IF(IHC-F) 1:50-200
 IF(ICC) 1:50-200
 ICC 1:100-500
- 
                                            限制
- 仅限研究用
 
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    - 
                                            状态
- Liquid
- 
                                            浓度
- 1 μg/μL
- 
                                            缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
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                                            储存液
- ProClin
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                                            注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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                                            储存条件
- 4 °C,-20 °C
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                                            储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
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                                            有效期
- 12 months
 
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    - GPR161 (G Protein-Coupled Receptor 161 (GPR161))
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                                            别名
- GPR161
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                                            背景
- 
                        Synonyms: RE2, G-protein coupled receptor 161, G-protein coupled receptor RE2, GPR161 Background: Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling. Its ligand is unknown (By similarity). 
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                                            基因ID
- 23432
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                                            UniProt
- Q8N6U8
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                                            途径
- cAMP Metabolic Process
 抗原
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