Optimal conditions should be determined by the investigator.
限制
仅限研究用
状态
Liquid
浓度
Lot specific
缓冲液
Supplied as a liquid in 100 mM BBS, pH 8.2.
储存条件
4 °C
储存方法
Store at 4 °C.
抗原
CD8 alpha (CD8A)
(CD8a Molecule (CD8A))
别名
CD8a
背景
CD8a (Cluster of Differentiation 8a), is a human gene. The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain isoforms. Two alternative transcripts encoding distinct isoforms, one membrane associated and one secreted, have been identified. Synonyms: Monoclonal CD8a antibody, Anti-CD8a antibody, Ly2 antibody.