CD300a 抗体
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北京 101111
Quick Overview for CD300a 抗体 (ABIN206697)
抗原
See all CD300a (CD300A) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- Recognizes human CD300a, otherwise known as IRp60 (inhibitory receptor protein 60), a 60kD transmembrane glycoprotein expressed by natural killer cells (NK), T and B cell subsets, monocytes, neutrophils, macrophages, granulocytes, dendritic cells (DC) and mast cells. Studies have shown that the cross-linking of CD300a on NK results in a down-regulation of their cytolytic activity, whilst cross-linking of CD300a on mast cells, inhibits IgE-induced degranulation and SCF-mediated survival. Furthermore, cross-linking of CD300a on the surface of eosinophils has been shown to significantly inhibit their survival, chemotaxis and activation in response to certain inflammatory cytokines, whilst eosinophil-derived MBP (major basic protein) and EDN (neurotoxin), can down-regulate CD300a expression on mast cells in vitro.
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纯化方法
- Protein A purified
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免疫原
- Human HPB acute lymphoid leukaemia cell line.
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亚型
- IgG1
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anti-CD300a (CD300A) (AA 18-180) antibody
CD300A 适用: 人 ELISA 宿主: 小鼠 Monoclonal 7H8E4 unconjugated
anti-CD300a (CD300A) (AA 18-180) antibodyCD300A 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-CD300a (CD300A) antibody (PE)CD300A 适用: 人 FACS 宿主: 小鼠 Monoclonal P192 PE
anti-CD300a (CD300A) antibodyCD300A 适用: 人 WB, FACS 宿主: 小鼠 Monoclonal MEM-260 unconjugated
anti-CD300a (CD300A) (Internal Region) antibodyCD300A 适用: 人 WB, ICC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-CD300a (CD300A) (AA 1-299) antibodyCD300A 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-CD300a (CD300A) antibody (APC)CD300A 适用: 人 FACS 宿主: 小鼠 Monoclonal MEM-260 APC
anti-CD300a (CD300A) antibody (PE)CD300A 适用: 人 FACS 宿主: 小鼠 Monoclonal MEM-260 PE
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应用备注
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Approved: Flo, WB
Usage: Flow Cytometry: Use 10 μL of the suggested working dilution to label 1x10^6 cells in 100 μL. Method sheets are available on request. Western Blot: LS-C45034 detects a band of approximately 60kD in HPB cell lysates under non-reducing conditions. -
说明
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Target Species of Antibody: Human
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- PBS, pH 7.4, 0.09 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C,-20 °C
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储存方法
- 4°C or -20°C, Avoid freeze-thaw cycles.
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- CD300a (CD300A)
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别名
- CD300A
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背景
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Name/Gene ID: CD300A
Synonyms: CD300A, CD300a antigen, CD300a molecule, CMRF35-like molecule 8, CMRF35-H, CMRF35-H9, CLM-8, CMRF35H9, IGSF12, Inhibitory receptor protein 60, IRC2, IRC1, NK inhibitory receptor, CMRF-35-H9, CMRF-35H, CMRF35H, IRC1a, IRp60, Leukocyte membrane antigen -
基因ID
- 11314
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UniProt
- Q9UGN4
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途径
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
抗原
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