Complement C4d 抗体
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- 抗原 See all Complement C4d (C4d) products
- Complement C4d (C4d) (Complement Component C4d (C4d))
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This Complement C4d antibody is un-conjugated
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应用范围
- ELISA, Immunohistochemistry (IHC), Immunohistochemistry (Frozen Sections) (IHC (fro)), Flow Cytometry (FACS)
- 特异性
- Recognizes a neoantigen on the secreted protein complement component 4d (C4d). The complement 1 complex cleaves complement 4 (C4) to form C4b and C4a. C4b levels are strictly regulated. Single site cleavage of the C4b's alpha chain by Factor I forms iC4b and blocks C3 convertase, inhibiting opsonization and activation of the classical pathway. This requires C4 binding protein or CR1 as a cofactor. iC4b is further degraded into C4d and C4c. The short half life of C4d means that it is present in serum at high enough concentrations to make it a useful marker for classical complement activation. C4 has been linked to susceptibility to systemic lupus erythematosus.
- 纯化方法
- Protein A purified
- 免疫原
- Purified human C4d.
- 亚型
- IgG1
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 说明
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Target Species of Antibody: Human
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- Lot specific
- 缓冲液
- Borate buffered saline, pH 8.2 - 8.4, 0.02 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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- 抗原
- Complement C4d (C4d) (Complement Component C4d (C4d))
- 别名
- Complement C4d (C4d 产品)
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