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CD161 抗体

This anti-CD161 antibody (ABIN1981864) is a Mouse Monoclonal antibody detecting CD161 in FACS, WB, IHC (fro). Suitable for Human, Non-Human Primate.
产品编号 ABIN1981864
发货至: 中国

Quick Overview for CD161 抗体 (ABIN1981864)

抗原

See all CD161 (KLRB1) 抗体
CD161 (KLRB1) (Killer Cell Lectin-Like Receptor Subfamily B, Member 1 (KLRB1))

适用

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人, Non-Human Primate

宿主

  • 43
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小鼠

克隆类型

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单克隆

标记

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This CD161 antibody is un-conjugated

应用范围

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Flow Cytometry (FACS), Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro))

克隆位点

HP-3G10
  • 原理

    Anti-Hu CD161 Purified

    特异性

    The mouse monoclonal antibody HP-3G10 recognizes an extracellular epitope of CD161, a type II transmembrane C-type lectin receptor, expressed on the plasma membrane of NK cells, dendritic cells, activated monocytes and a subset of T cells as a disulphide-linked homodimer.

    交叉反应 (详细)

    Human, Non-Human Primates

    纯化方法

    Purified by protein-A affinity chromatography.

    纯度

    > 95 % (by SDS-PAGE)

    免疫原

    human NK cells

    亚型

    IgG1 kappa
  • 应用备注

    Flow cytometry: Recommended dilution: 1-4 μg/mL.

    限制

    仅限研究用
  • 浓度

    1 mg/mL

    缓冲液

    Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Do not freeze. Do not use after expiration date stamped on vial label.

    储存条件

    4 °C

    储存方法

    Store at 2-8°C. Do not freeze.
  • Tresoldi, DellAlbani, Stabilini, Jofra, Valle, Gagliani, Bondanza, Roncarolo, Battaglia: "Stability of human rapamycin-expanded CD4+CD25+ T regulatory cells." in: Haematologica, Vol. 96, Issue 9, pp. 1357-65, (2011) (PubMed).

    Germain, Meier, Jensen, Knapnougel, Poupon, Lazzari, Neisig, Håkansson, Dong, Wagtmann, Galsgaard, Spee, Braud: "Induction of lectin-like transcript 1 (LLT1) protein cell surface expression by pathogens and interferon-? contributes to modulate immune responses." in: The Journal of biological chemistry, Vol. 286, Issue 44, pp. 37964-75, (2011) (PubMed).

    Goetzl, Huang, Kon, Patel, Schwartz, Fast, Ferrucci, Madara, Taub, Longo: "Gender specificity of altered human immune cytokine profiles in aging." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 24, Issue 9, pp. 3580-9, (2010) (PubMed).

    Pozo, Valés-Gómez, Mavaddat, Williamson, Chisholm, Reyburn: "CD161 (human NKR-P1A) signaling in NK cells involves the activation of acid sphingomyelinase." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 176, Issue 4, pp. 2397-406, (2006) (PubMed).

  • 抗原

    CD161 (KLRB1) (Killer Cell Lectin-Like Receptor Subfamily B, Member 1 (KLRB1))

    别名

    CD161

    背景

    Killer cell lectin like receptor B1,CD161, also known as Nkrp1 (natural killer receptor protein 1) or Klrb1 (killer cell lectin-like receptor subfamily b member 1), is a disulphide-linked homodimeric receptor, which is involved in regulation of NK cell and NKT cell function. It is expressed on rat NK cells, subset of T cells, dendritic cells, and activated monocytes. Although human CD161 is expressed as one isoform, the rat CD161 has three isoforms, referred to as CD161a, b, and c. These proteins contain C-terminal C-type lectin extracellular domain, a transmembrane domain, and N-terminal intracellular domain, which contains ITIM motif, such as CD161b, and displays inhibitory function, or does not contain ITIM motif, thus also not the inhibitory function, such as CD161a.,NKRP1A, KLRB1, CLEC5B

    基因ID

    3820

    UniProt

    Q12918
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