CDK1 抗体 (Tyr15)
Our Local Distributor
北京 101111
Quick Overview for CDK1 抗体 (Tyr15) (ABIN197482)
抗原
See all CDK1 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- Tyr15
-
特异性
- CDC2 antibody detects endogenous levels of total CDC2 protein.
-
纯化方法
- Affinity chromatography
-
免疫原
- The antiserum was produced against synthesized non-phosphopeptide derived from human CDC2 around the phosphorylation site of tyrosine 15 (G-T-YP-G-V).
-
-
anti-Cyclin-Dependent Kinase 1 (CDK1) (AA 59-182) antibody
CDK1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 1 (CDK1) (AA 208-258) antibodyCDK1 适用: 人 WB, IHC, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 1 (CDK1) (pTyr15) antibodyCDK1 适用: 人, 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 1 (CDK1) (AA 211-297) antibodyCDK1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 1G10 unconjugated
anti-Cyclin-Dependent Kinase 1 (CDK1) (AA 1-297) antibodyCDK1 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 1A4-1A9 unconjugated
anti-Cyclin-Dependent Kinase 1 (CDK1) (AA 1-297) antibodyCDK1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 1 (CDK1) (AA 211-297) antibodyCDK1 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 8F1 unconjugated
anti-Cyclin-Dependent Kinase 1 (CDK1) antibodyCDK1 适用: 人, 小鼠, 大鼠, 猴 WB, IHC, ELISA, ICC 宿主: 小鼠 Monoclonal 2G9 unconjugated
anti-Cyclin-Dependent Kinase 1 (CDK1) (AA 66-297) antibodyCDK1 适用: 人, 小鼠, 大鼠 WB, IHC, IF, FACS, ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 1 (CDK1) (AA 201-297) antibodyCDK1 适用: 人, 小鼠, 大鼠, 犬, 绵羊 WB, ELISA, IHC (p), FACS, IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
-
Western Blot: 1: 500approx. 1: 1000. Immunohistochemistry: 1: 50approx. 1: 100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
-
-
-
浓度
- 1.0 mg/mL
-
缓冲液
- PBS (without Mg2+ and Ca2+), pH 7.4 containing 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
-
储存液
- Sodium azide
-
注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
注意事项
- Avoid repeated freezing and thawing.
-
储存条件
- -20 °C
-
-
- CDK1 (Cyclin-Dependent Kinase 1 (CDK1))
-
别名
- CDK1
-
背景
- The cell division control protein cdc2, also known as cyclin dependent kinase 1 (Cdk1) or p34/cdk1, plays a key role in the control of the eukaryotic cell cycle, where it is required for entry into S phase and mitosis. Cdc2 exists as a complex with both cyclin A and cyclin B. The best characterized of these associations is the Cdc2 p34 cyclin B complex, which is required for the G2 to M phase transition. Activation of Cdc2 is controlled at several steps including cyclin binding and phosphorylation of threonine 161. However, the critical regulatory step in activating cdc2 during progression into mitosis appears to be dephosphorylation of Tyr15 and Tyr14. Phosphorylation at Tyr15 and inhibition of Cdc2 is carried out by WEE1 and MIK protein kinases while Tyr15 dephosphorylation and activation of Cdc2 is carried out by the cdc25 phosphatase. The isoform CDC2deltaT is found in breast cancer tissues. Furthermore, cdc2/Cdk1 is a key mediator of neuronal cell death in brain development and degeneration.Synonyms: CDC2, CDC28A, CDK1, CDKN1, Cell division control protein 2 homolog, Cell division protein kinase 1, Cyclin-dependent kinase 1, P34CDC2, p34 protein kinase
-
基因ID
- 983
-
NCBI登录号
- NP_001777
-
UniProt
- P06493
-
途径
- Cell Division Cycle, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Mitotic G1-G1/S Phases, DNA Replication, M Phase, Toll-Like Receptors Cascades, Synthesis of DNA
抗原
-
