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FOXO1 抗体 (AA 254-258)

The 兔 多克隆 anti-FOXO1 antibody (ABIN197334) specifically detects FOXO1 in WB, IF 和 IHC (p). The antibody is reactive with 人 samples.
产品编号 ABIN197334
发货至: 中国
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Quick Overview for FOXO1 抗体 (AA 254-258) (ABIN197334)

抗原

See all FOXO1 抗体
FOXO1 (Forkhead Box O1 (FOXO1))

适用

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宿主

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克隆类型

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多克隆

标记

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This FOXO1 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
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    AA 254-258

    特异性

    This antibody detects endogenous levels of total FKHR protein.

    交叉反应 (详细)

    Species reactivity (tested):Human tissue and cell lines

    纯化方法

    Immunoaffinity Chromatography using epitope-specific immunogen.

    免疫原

    Peptide Sequence around amino acids 254~258 (A-A-S-M-D) derived from Human FKHR/FOXO1A
  • 应用备注

    Western blot: 1/500-1/1000. Immunofluorescence: 1/100-1/200. Immunohistochemistry on Paraffin-Embedded Sections: 1/50-1/100.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.

    限制

    仅限研究用
  • 浓度

    1.0 mg/mL

    缓冲液

    PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % Sodium Azide and 50 % Glycerol.

    储存液

    Sodium azide

    注意事项

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freezing and thawing.

    储存条件

    -20 °C

    储存方法

    Store the antibody (in aliquots) at -20 °C.
  • 抗原

    FOXO1 (Forkhead Box O1 (FOXO1))

    别名

    FOXO1A

    背景

    FOXO1A (FKHR or ForkHead in Rhabdomyosarcoma) is a 70 kDa protein which is a member of a subfamily of the forkhead homeotic gene family of transcription factors. Recent studies have shown that this protein can act as either a coactivator or a corepressor of nuclear receptor activity. This action is mediated through the LXXLL motif found in the C terminus of the FOXO1A protein. The specific function of the gene has not yet been determined, however, it may play a role in myogenic growth and differentiation. Chromosomal aberrations involving FOXO1A are a cause of rhabdomyosarcoma 2 (RMS2), also known as alveolar rhabdomyosarcoma.Synonyms: FKHR, FOXO1, Forkhead Box Protein O1, Forkhead Box Protein O1A, Forkhead in Rhabdomyosarcoma

    分子量

    78-82 KDa

    基因ID

    2308

    NCBI登录号

    NP_002006

    UniProt

    Q12778

    途径

    PI3K-Akt Signaling, Cell Division Cycle, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Carbohydrate Homeostasis, Chromatin Binding, Regulation of Carbohydrate Metabolic Process, CXCR4-mediated Signaling Events, BCR Signaling
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