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GATA1 抗体 (Ser310)

This anti-GATA1 antibody is a 兔 多克隆 antibody detecting GATA1 in WB. Suitable for 人 和 小鼠.
产品编号 ABIN197170
发货至: 中国

Quick Overview for GATA1 抗体 (Ser310) (ABIN197170)

抗原

See all GATA1 抗体
GATA1 (GATA Binding Protein 1 (Globin Transcription Factor 1) (GATA1))

适用

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人, 小鼠

宿主

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克隆类型

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多克隆

标记

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This GATA1 antibody is un-conjugated

应用范围

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Western Blotting (WB)
  • 抗原表位

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    Ser310

    特异性

    GATA1 antibody detects endogenous levels of total GATA1 protein.

    纯化方法

    Affinity-chromatography using epitope-specific immunogen

    免疫原

    The antiserum was produced against synthesized non-phosphopeptide derived from human GATA1 around the phosphorylation site of serine 310 (K-A-SP-G-K).
  • 应用备注

    Western Blot: 1: 500approx. 1: 1000.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.

    限制

    仅限研究用
  • 浓度

    1.0 mg/mL

    缓冲液

    PBS(without Mg2+ and Ca2+), pH 7.4 containing 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol

    储存液

    Sodium azide

    注意事项

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freezing and thawing.

    储存条件

    -20 °C
  • 抗原

    GATA1 (GATA Binding Protein 1 (Globin Transcription Factor 1) (GATA1))

    别名

    GATA1

    背景

    GATA1 (Globin transcription factor 1) is a Cys2/Cys2 zinc finger DNA binding protein that is expressed primarily in erythroid, megakaryocytic, mast cells and eosinophilic cells. It belongs to the GATA family of transcription factors. GATA1 is a transcriptional activator which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence [AT]GATA[AG] within regulatory regions of globin genes and of other genes expressed in erythroid cells. The protein also plays an important role in erythroid development by regulating the switch from fetal hemoglobin production to adult hemoglobin. Mutations in this gene have been associated with X-linked dyserythropoietic anemia and thrombocytopenia. Acquired somatic mutations in GATA1 occur in virtually all children with Down's Syndrome, congenital transient myeloproliferative syndrome (TMD) and acute megakaryocytic leukemia.Synonyms: ERYF1, Eryf1, Erythroid transcription factor, GATA-1, GATA-binding factor 1, GF-1, GF1, NF-E1 DNA-binding protein

    基因ID

    2623

    NCBI登录号

    NP_002040

    UniProt

    P15976

    途径

    Cellular Response to Molecule of Bacterial Origin
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