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Metabotropic Glutamate Receptor 6 抗体

This anti-Metabotropic Glutamate Receptor 6 antibody is a 兔 多克隆 antibody detecting Metabotropic Glutamate Receptor 6 in WB 和 IHC. Suitable for 人. This Primary Antibody has been cited in 3+ publications.
产品编号 ABIN1944817
发货至: 中国

Quick Overview for Metabotropic Glutamate Receptor 6 抗体 (ABIN1944817)

抗原

See all Metabotropic Glutamate Receptor 6 (GRM6) 抗体
Metabotropic Glutamate Receptor 6 (GRM6) (Glutamate Receptor, Metabotropic 6 (GRM6))

适用

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宿主

  • 34
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克隆类型

  • 35
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多克隆

标记

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This Metabotropic Glutamate Receptor 6 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (IHC)
  • 亚型

    IgG1
  • 应用备注

    WB: 1:1000. IHC: 1:50-1:100

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02 % sodium azide and 50 % glycerol.

    储存液

    Sodium azide

    注意事项

    WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

    储存条件

    4 °C,-20 °C
  • Devi, Markandeya, Maddodi, Dhingra, Vardi, Balijepalli, Setaluri: "Metabotropic glutamate receptor 6 signaling enhances TRPM1 calcium channel function and increases melanin content in human melanocytes." in: Pigment cell & melanoma research, Vol. 26, Issue 3, pp. 348-56, (2013) (PubMed).

    Dryja, McGee, Berson, Fishman, Sandberg, Alexander, Derlacki, Rajagopalan: "Night blindness and abnormal cone electroretinogram ON responses in patients with mutations in the GRM6 gene encoding mGluR6." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 13, pp. 4884-9, (2005) (PubMed).

    Hashimoto, Inazawa, Okamoto, Tagawa, Bessho, Honda, Nakanishi: "The whole nucleotide sequence and chromosomal localization of the gene for human metabotropic glutamate receptor subtype 6." in: The European journal of neuroscience, Vol. 9, Issue 6, pp. 1226-35, (1997) (PubMed).

  • 抗原

    Metabotropic Glutamate Receptor 6 (GRM6) (Glutamate Receptor, Metabotropic 6 (GRM6))

    别名

    mGluR6

    背景

    G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity (By similarity). Signaling stimulates TRPM1 channel activity and Ca(2+) uptake. Required for normal vision.

    分子量

    95468 Da

    基因ID

    2916

    UniProt

    O15303
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