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Thrombomodulin 抗体

Cited in 5+ publications. This 兔 多克隆 anti-Thrombomodulin antibody specifically detects Thrombomodulin in WB. The antibody is reactive with 人 samples.
产品编号 ABIN1944809
发货至: 中国
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Room 801-803
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Tel +86 (0512) 65829739 传真 +86 (010) 6788 5057

Quick Overview for Thrombomodulin 抗体 (ABIN1944809)

抗原

See all Thrombomodulin (THBD) 抗体
Thrombomodulin (THBD)

适用

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宿主

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克隆类型

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多克隆

标记

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This Thrombomodulin antibody is un-conjugated

应用范围

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Western Blotting (WB)
  • 亚型

    IgG1
  • 应用备注

    WB: 1:1000

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02 % sodium azide and 50 % glycerol.

    储存液

    Sodium azide

    注意事项

    WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

    储存条件

    4 °C,-20 °C
  • Deloukas, Matthews, Ashurst, Burton, Gilbert, Jones, Stavrides, Almeida, Babbage, Bagguley, Bailey, Barlow, Bates, Beard, Beare, Beasley, Bird, Blakey, Bridgeman, Brown, Buck, Burrill, Butler, Carder et al.: "The DNA sequence and comparative analysis of human chromosome 20. ..." in: Nature, Vol. 414, Issue 6866, pp. 865-71, (2002) (PubMed).

    Shirai, Shiojiri, Ito, Yamamoto, Kusumoto, Deyashiki, Maruyama, Suzuki: "Gene structure of human thrombomodulin, a cofactor for thrombin-catalyzed activation of protein C." in: Journal of biochemistry, Vol. 103, Issue 2, pp. 281-5, (1988) (PubMed).

    Suzuki, Kusumoto, Deyashiki, Nishioka, Maruyama, Zushi, Kawahara, Honda, Yamamoto, Horiguchi: "Structure and expression of human thrombomodulin, a thrombin receptor on endothelium acting as a cofactor for protein C activation." in: The EMBO journal, Vol. 6, Issue 7, pp. 1891-7, (1987) (PubMed).

    Jackman, Beeler, Fritze, Soff, Rosenberg: "Human thrombomodulin gene is intron depleted: nucleic acid sequences of the cDNA and gene predict protein structure and suggest sites of regulatory control." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 84, Issue 18, pp. 6425-9, (1987) (PubMed).

    Wen, Dittman, Ye, Deaven, Majerus, Sadler: "Human thrombomodulin: complete cDNA sequence and chromosome localization of the gene." in: Biochemistry, Vol. 26, Issue 14, pp. 4350-7, (1987) (PubMed).

  • 抗原

    Thrombomodulin (THBD)

    别名

    THBD

    背景

    Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.

    分子量

    60329 Da

    基因ID

    7056

    UniProt

    P07204
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