Thrombomodulin 抗体
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北京 101111
Quick Overview for Thrombomodulin 抗体 (ABIN1944809)
抗原
See all Thrombomodulin (THBD) 抗体适用
宿主
克隆类型
标记
应用范围
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亚型
- IgG1
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应用备注
- WB: 1:1000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
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储存条件
- 4 °C,-20 °C
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: "The DNA sequence and comparative analysis of human chromosome 20. ..." in: Nature, Vol. 414, Issue 6866, pp. 865-71, (2002) (PubMed).
: "Gene structure of human thrombomodulin, a cofactor for thrombin-catalyzed activation of protein C." in: Journal of biochemistry, Vol. 103, Issue 2, pp. 281-5, (1988) (PubMed).
: "Structure and expression of human thrombomodulin, a thrombin receptor on endothelium acting as a cofactor for protein C activation." in: The EMBO journal, Vol. 6, Issue 7, pp. 1891-7, (1987) (PubMed).
: "Human thrombomodulin gene is intron depleted: nucleic acid sequences of the cDNA and gene predict protein structure and suggest sites of regulatory control." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 84, Issue 18, pp. 6425-9, (1987) (PubMed).
: "Human thrombomodulin: complete cDNA sequence and chromosome localization of the gene." in: Biochemistry, Vol. 26, Issue 14, pp. 4350-7, (1987) (PubMed).
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: "The DNA sequence and comparative analysis of human chromosome 20. ..." in: Nature, Vol. 414, Issue 6866, pp. 865-71, (2002) (PubMed).
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- Thrombomodulin (THBD)
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别名
- THBD
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背景
- Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.
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分子量
- 60329 Da
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基因ID
- 7056
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UniProt
- P07204
抗原
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