USP11 抗体 (N-Term)
Quick Overview for USP11 抗体 (N-Term) (ABIN1944797)
抗原
See all USP11 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 32-300, N-Term
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纯化方法
- This antibody is purified through a protein G column, followed by dialysis against PBS.
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免疫原
- This USP11 antibody is generated from a mouse immunized with a KLH conjugated synthetic peptide between 32-300 amino acids from the N-terminal region of human USP11.
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亚型
- IgG1 kappa
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应用备注
- WB: 1:1000. FC: 1:25
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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有效期
- 6 months
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: "The deubiquitinating enzyme USP11 controls an IkappaB kinase alpha (IKKalpha)-p53 signaling pathway in response to tumor necrosis factor alpha (TNFalpha)." in: The Journal of biological chemistry, Vol. 282, Issue 47, pp. 33943-8, (2007) (PubMed).
: "BRCA2 is ubiquitinated in vivo and interacts with USP11, a deubiquitinating enzyme that exhibits prosurvival function in the cellular response to DNA damage." in: Molecular and cellular biology, Vol. 24, Issue 17, pp. 7444-55, (2004) (PubMed).
: "Structural and functional characterization of the USP11 deubiquitinating enzyme, which interacts with the RanGTP-associated protein RanBPM." in: The Biochemical journal, Vol. 367, Issue Pt 1, pp. 87-95, (2002) (PubMed).
: "A ubiquitin C-terminal hydrolase gene on the proximal short arm of the X chromosome: implications for X-linked retinal disorders." in: Human molecular genetics, Vol. 5, Issue 4, pp. 533-8, (1996) (PubMed).
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: "The deubiquitinating enzyme USP11 controls an IkappaB kinase alpha (IKKalpha)-p53 signaling pathway in response to tumor necrosis factor alpha (TNFalpha)." in: The Journal of biological chemistry, Vol. 282, Issue 47, pp. 33943-8, (2007) (PubMed).
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- USP11 (Ubiquitin Specific Peptidase 11 (USP11))
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别名
- USP11
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背景
- Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Inhibits the degradation of target proteins by the proteasome. Plays a role in the regulation of pathways leading to NF-kappa-B activation. Plays a role in the regulation of DNA repair after double-stranded DNA breaks.
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分子量
- 109817
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基因ID
- 8237
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UniProt
- P51784
抗原
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