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ING4 抗体 (C-Term)

This anti-ING4 antibody is a 兔 多克隆 antibody detecting ING4 in WB 和 IHC (p). Suitable for 人. This Primary Antibody has been cited in 2+ publications.
产品编号 ABIN1944775
发货至: 中国

Quick Overview for ING4 抗体 (C-Term) (ABIN1944775)

抗原

See all ING4 抗体
ING4 (Inhibitor of Growth Family, Member 4 (ING4))

适用

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宿主

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克隆类型

  • 29
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多克隆

标记

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This ING4 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

克隆位点

RB47839
  • 抗原表位

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    AA 162-195, C-Term

    预测反应

    B, C, M

    纯化方法

    This antibody is purified through a protein A column, followed by peptide affinity purification.

    免疫原

    This ING4 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 162-195 amino acids from the C-terminal region of human ING4.

    亚型

    Ig Fraction
  • 应用备注

    WB: 1:1000. IHC-P: 1:25

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    有效期

    6 months
  • Raho, Miranda, Tamborini, Pierotti, Greco: "Detection of novel mRNA splice variants of human ING4 tumor suppressor gene." in: Oncogene, Vol. 26, Issue 36, pp. 5247-57, (2007) (PubMed).

    Shiseki, Nagashima, Pedeux, Kitahama-Shiseki, Miura, Okamura, Onogi, Higashimoto, Appella, Yokota, Harris: "p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity." in: Cancer research, Vol. 63, Issue 10, pp. 2373-8, (2003) (PubMed).

  • 抗原

    ING4 (Inhibitor of Growth Family, Member 4 (ING4))

    别名

    ING4

    背景

    Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may function in DNA replication. May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation. Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA. May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC. Represses hypoxia inducible factor's (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1).

    分子量

    28530

    基因ID

    51147

    UniProt

    Q9UNL4
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