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CD24 抗体 (FITC)

CD24 适用: 人 FACS 宿主: 小鼠 Monoclonal SN3 FITC
产品编号 ABIN192413
发货至: 中国
  • 抗原 See all CD24 抗体
    CD24 (CD24 Molecule (CD24))
    适用
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    宿主
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    小鼠
    克隆类型
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    单克隆
    标记
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    This CD24 antibody is conjugated to FITC
    应用范围
    • 84
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    Flow Cytometry (FACS)
    特异性
    The antibody SN3 reacts with CD24, a 35-45 kDa heavily glycosylated cell surface antigen. CD24 is expressed by granulocytes, B lymphocytes and by some activated T cells and T cell malignancies. It is not expressed on human thymocytes.
    交叉反应 (详细)
    Human
    纯化方法
    Purified antibody is conjugated with fluorescein isothiocyanate (FITC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
    免疫原
    Glycoproteins purified from human NALM-1 cell line.
    克隆位点
    SN3
    亚型
    IgG1
  • 应用备注
    Flow cytometry: The reagent is designed for analysis of human blood cells using 20 μL reagent / 100 μL of whole blood or 106 cells in a suspension. The content of a vial (2 ml) is sufficient for 100 tests.
    说明

    The purified antibody is conjugated with Fluorescein isothiocyanate (FITC) under optimum conditions. The reagent is free of unconjugated FITC and adjusted for direct use. No reconstitution is necessary.

    限制
    仅限研究用
  • 溶解方式
    No reconstitution is necessary.
    缓冲液
    Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Do not freeze.
    Avoid prolonged exposure to light.
    储存条件
    4 °C
    储存方法
    Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
  • Všianská, Říhová, Varmužová, Suská, Kryukov, Mikulášová, Kupská, Penka, Pour, Adam, Hájek: "Analysis of B-cell subpopulations in monoclonal gammopathies." in: Clinical lymphoma, myeloma & leukemia, Vol. 15, Issue 4, pp. e61-71, (2015) (PubMed).

    Maliar, Servais, Waks, Chmielewski, Lavy, Altevogt, Abken, Eshhar: "Redirected T cells that target pancreatic adenocarcinoma antigens eliminate tumors and metastases in mice." in: Gastroenterology, Vol. 143, Issue 5, pp. 1375-84.e1-5, (2012) (PubMed).

    Qiu, Low, Chang, Strohsnitter, Anderson, Edmiston, Adami, Ekbom, Hall, Lagiou, Trichopoulos, Hsieh: "Novel measurements of mammary stem cells in human umbilical cord blood as prospective predictors of breast cancer susceptibility in later life." in: Annals of oncology : official journal of the European Society for Medical Oncology / ESMO, Vol. 23, Issue 1, pp. 245-50, (2011) (PubMed).

    Solvason, Kearney: "The human fetal omentum: a site of B cell generation." in: The Journal of experimental medicine, Vol. 175, Issue 2, pp. 397-404, (1992) (PubMed).

    Fischer, Majdic, Gadd, Knapp: "Signal transduction in lymphocytic and myeloid cells via CD24, a new member of phosphoinositol-anchored membrane molecules." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 144, Issue 2, pp. 638-41, (1990) (PubMed).

    Barcos, Pollard, Fukukawa, Seon: "Follicular mantle zone cell subpopulations detected by monoclonal antibody SN3." in: Hematological oncology, Vol. 4, Issue 4, pp. 251-9, (1987) (PubMed).

    Fukukawa, Matsuzaki, Haruta, Hara, Seon: "New monoclonal antibodies SN3, SN3a, and SN3b directed to sialic acid of glycoprotein on human non-T leukemia cells." in: Experimental hematology, Vol. 14, Issue 9, pp. 850-5, (1986) (PubMed).

  • 抗原
    CD24 (CD24 Molecule (CD24))
    别名
    CD24 (CD24 产品)
    别名
    CD24A antibody, Cd24a antibody, CD24 molecule antibody, CD24 antibody, Cd24 antibody
    背景
    CD24 Molecule,CD24, also known as heat-stable antigen (HSA) or nectadorin, is a small mucin-like GPI-anchored extracellular membrane glycoprotein expressed on several cell types, including B cells. When B cells are activated and induced to further maturation, however, CD24 begins to disappear. CD24 seems to act as a gate-keeper for lipid rafts, thereby regulating the activity of integrins and other proteins such as the chemokine receptor CXCR4, it is also a ligand for P-selectin. CD24 triggering induces apoptosis of B cell precursors but not in mature resting B cells, where it instead inhibits their ability to proliferate in response to activation. CD24 expression is associated with invasiveness and poorer prognosis of carcinomas and is a marker of exosomes secreted into urine and amniotic fluid.,HSA, nectadorin, SCLC4
    基因ID
    100133941
    UniProt
    P25063
    途径
    Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation
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