HSP70 抗体
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北京 101111
Quick Overview for HSP70 抗体 (ABIN191987)
抗原
See all HSP70 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- This antibody detects HSP70.
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产品特性
- Synonyms: Heat Shock Protein 70
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纯化方法
- Protein G chromatography
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免疫原
- HSP70 from Geodia cydonium
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亚型
- IgG1
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应用备注
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ELISA: 1: 5,000. Western blot: 1: 500. Immunoprecipitation: 1: 50. Immunohistochemistry: 1: 50.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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溶解方式
- Restore in aqua bidest to 1 mg/mL.
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缓冲液
- 50 mM TRIS pH 7.4
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储存条件
- 4 °C/-20 °C
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储存方法
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Store lyophilized at 2 - 8 °C and reconstituted at -20 °C. Avoid repeated freezing andthawing.
Shelf life: One year from despatch. -
有效期
- 12 months
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- HSP70 (Heat Shock Protein 70 (HSP70))
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别名
- Hsp70
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背景
- Heat shock proteins (HSPs) or stress response proteins (SRPs) are synthesized in variety of environmental and pathophysiological stressful conditions. Many HSPs are involved in processes such as protein denaturation-renaturation, folding-unfolding, transport-translocation, activation-inactivation, and secretion. HSP70 is found to be associated with steroid receptors, actin, p53, polyoma T antigen, nucleotides, and other unknown proteins. Also, HSP70 has been shown to be involved in protective roles against thermal stress, cytotoxic drugs, and other damaging conditions. Heat shock proteins are produced by prokaryotic and eukaryotic cells, and are among the most conserved molecules in phylogeny. Eukaryotic cells contain an HSP70 multigene that differ in their intracellular location and regulation. Members of the HSP70 family play a major role in the folding, unfolding and translocation of polypeptides as well as in the assembly and disassembly of oligomeric protein complexes, as well as in the immune response. HSP72 was found to increase dramatically in the brains of Alzheimer's disease patients, and was localized exclusively in neuritic plaques and neurofibrillary tangles. HSP70 concentrates in nuclei during heat shock and returns to the cytoplasm when the shock is removed.Synonyms: Heat Shock Protein 70
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UniProt
- Q24952
抗原
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