RIPK2 抗体 (AA 508-522)
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Quick Overview for RIPK2 抗体 (AA 508-522) (ABIN1886884)
抗原
See all RIPK2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 508-522
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纯化方法
- Affinity chromatography purified via peptide column
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免疫原
- Peptide corresponding to amino acids 508 to 522 of human origin.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS containing 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
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注意事项
- Avoid freezing and thawing repeatly.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at 4 °C for short term use.Store at -20 °C for long term preservation.
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- RIPK2 (Receptor-Interacting Serine-threonine Kinase 2 (RIPK2))
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别名
- RICK
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背景
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Apoptosis is mediated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases.DD-containing serine/threonine kinase RIP regulates Fas-induced apoptosis.A novel CARD-containing serine/threonine kinase was recently identified and designated RICK/RIP2/CARDIAK for RIP-like interacting CLARP kinase, receptor interacting protein-2, and CARD-containing ICE associated kinase, respectively.RICK contains an N-terminal kinase catalytic domain and a C-terminal CARD domain.Overexpression of RICK induced apoptosis and activation of NF-kappaB and JNK.RICK interacts with members of the TRAF family, CLARP and caspase-1.Thus, RICK represents a novel kinase that regulates TNF and Fas induced-apoptosis and that is involved in the generation of proinflammatory cytokine IL-1beta.The messenger RNA of RICK is expressed in multiple human tissues.
Synonyms: RIP2 -
分子量
- 60 kDa
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途径
- TCR Signaling, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Toll-Like Receptors Cascades
抗原
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