B-Cell Linker 抗体 (AA 394-456)
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北京 101111
Quick Overview for B-Cell Linker 抗体 (AA 394-456) (ABIN1886429)
抗原
See all B-Cell Linker (BLNK) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 394-456
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纯化方法
- Purified by antigen-affinity chromatography.
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免疫原
- Synthetic peptide contain a sequence corresponding to a region within amino acids 394 and 456 of BLNK
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应用备注
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Suggested dilutions:
Western blotting: 1.500-1.3000
Immunofluorescence: 1.100-1.200 -
限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- 1 x PBS, 40 % Glycerol (pH 7.0).0.01 % Thimerosal was added as a preservative.
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储存液
- Thimerosal (Merthiolate)
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注意事项
- Biohazard Informations: This product contains thimerosal which is hazardous.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
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- B-Cell Linker (BLNK)
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别名
- B-cell linker protein
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背景
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This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development.This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions.The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation.Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked.Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia.Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq]
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分子量
- 50 kDa
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基因ID
- 29760
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NCBI登录号
- NP_037446, NM_013314
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途径
- BCR Signaling
抗原
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