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RAG2 抗体 (AA 271-519)

This 兔 多克隆 anti-RAG2 antibody specifically detects RAG2 in WB, IF 和 IHC. The antibody is reactive with 人 samples.
产品编号 ABIN1886297
发货至: 中国
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Quick Overview for RAG2 抗体 (AA 271-519) (ABIN1886297)

抗原

See all RAG2 抗体
RAG2 (Recombination Activating Gene 2 (RAG2))

适用

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宿主

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克隆类型

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多克隆

标记

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This RAG2 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC)
  • 抗原表位

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    AA 271-519

    纯化方法

    Purified by antigen-affinity chromatography.

    免疫原

    Recombinant protein fragment contain a sequence corresponding to a region within amino acids 271 and 519 of RAG2
  • 应用备注

    Suggested dilutions:
    Western blotting: 1.500-1.3000
    Immunohistochemistry: 1.100-1.500
    Immunofluorescence: 1.100-1.200

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    0.1 M Tris-buffered saline with 10 % Glycerol (pH 7.0).0.01 % Thimerosal was added as a preservative.

    储存液

    Thimerosal (Merthiolate)

    注意事项

    Biohazard Informations: This product contains thimerosal which is hazardous.

    储存条件

    4 °C/-20 °C

    储存方法

    Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
  • 抗原

    RAG2 (Recombination Activating Gene 2 (RAG2))

    别名

    RAG2

    背景

    This gene encodes a protein that is involved in the initiation of V(D)J recombination during B and T cell development.This protein forms a complex with the product of the adjacent recombination activating gene 1, and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences.The recombination activating gene 1 component is thought to contain most of the catalytic activity, while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA.A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components, specifically with histone H3 that is trimethylated at lysine 4.Mutations in this gene cause Omenn syndrome, a form of severe combined immunodeficiency associated with autoimmune-like symptoms.[provided by RefSeq]

    分子量

    59 kDa

    基因ID

    5897

    NCBI登录号

    NP_000527, NM_000536

    途径

    Chromatin Binding, Production of Molecular Mediator of Immune Response
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