RAG2 抗体 (AA 271-519)
Our Local Distributor
北京 101111
Quick Overview for RAG2 抗体 (AA 271-519) (ABIN1886297)
抗原
See all RAG2 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 271-519
-
纯化方法
- Purified by antigen-affinity chromatography.
-
免疫原
- Recombinant protein fragment contain a sequence corresponding to a region within amino acids 271 and 519 of RAG2
-
-
-
-
应用备注
-
Suggested dilutions:
Western blotting: 1.500-1.3000
Immunohistochemistry: 1.100-1.500
Immunofluorescence: 1.100-1.200 -
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- 0.1 M Tris-buffered saline with 10 % Glycerol (pH 7.0).0.01 % Thimerosal was added as a preservative.
-
储存液
- Thimerosal (Merthiolate)
-
注意事项
- Biohazard Informations: This product contains thimerosal which is hazardous.
-
储存条件
- 4 °C/-20 °C
-
储存方法
- Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
-
-
- RAG2 (Recombination Activating Gene 2 (RAG2))
-
别名
- RAG2
-
背景
-
This gene encodes a protein that is involved in the initiation of V(D)J recombination during B and T cell development.This protein forms a complex with the product of the adjacent recombination activating gene 1, and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences.The recombination activating gene 1 component is thought to contain most of the catalytic activity, while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA.A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components, specifically with histone H3 that is trimethylated at lysine 4.Mutations in this gene cause Omenn syndrome, a form of severe combined immunodeficiency associated with autoimmune-like symptoms.[provided by RefSeq]
-
分子量
- 59 kDa
-
基因ID
- 5897
-
NCBI登录号
- NP_000527, NM_000536
-
途径
- Chromatin Binding, Production of Molecular Mediator of Immune Response
抗原
-