F13A1 抗体 (AA 245-494)
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北京 101111
Quick Overview for F13A1 抗体 (AA 245-494) (ABIN1886255)
抗原
See all F13A1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 245-494
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纯化方法
- Purified by antigen-affinity chromatography.
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免疫原
- Recombinant protein fragment contain a sequence corresponding to a region within amino acids 245 and 494 of Human F13A1
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应用备注
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Suggested dilutions:
Western blotting: 1.500-1.3000
Immunofluorescence: 1.100-1.200 -
限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- 0.1 M Tris-buffered saline with 10 % Glycerol (pH 7.0).0.01 % Thimerosal was added as a preservative.
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储存液
- Thimerosal (Merthiolate)
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注意事项
- Biohazard Informations: This product contains thimerosal which is hazardous.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
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- F13A1 (Coagulation Factor XIII, A1 Polypeptide (F13A1))
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别名
- Factor XIIIa
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背景
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This gene encodes the coagulation factor XIII A subunit.Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade.Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits.The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules.Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin.Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII.This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot.It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin.Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits, and type II deficiency, characterized by the lack of the A subunit alone.These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion.[provided by RefSeq]
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分子量
- 83 kDa
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基因ID
- 2162
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NCBI登录号
- NP_000120, NM_000129
抗原
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