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F13A1 抗体 (AA 245-494)

This anti-F13A1 antibody is a 兔 多克隆 antibody detecting F13A1 in WB 和 IF. Suitable for 人.
产品编号 ABIN1886255
发货至: 中国

Quick Overview for F13A1 抗体 (AA 245-494) (ABIN1886255)

抗原

See all F13A1 抗体
F13A1 (Coagulation Factor XIII, A1 Polypeptide (F13A1))

适用

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宿主

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克隆类型

  • 52
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多克隆

标记

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This F13A1 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunofluorescence (IF)
  • 抗原表位

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    AA 245-494

    纯化方法

    Purified by antigen-affinity chromatography.

    免疫原

    Recombinant protein fragment contain a sequence corresponding to a region within amino acids 245 and 494 of Human F13A1
  • 应用备注

    Suggested dilutions:
    Western blotting: 1.500-1.3000
    Immunofluorescence: 1.100-1.200

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    0.1 M Tris-buffered saline with 10 % Glycerol (pH 7.0).0.01 % Thimerosal was added as a preservative.

    储存液

    Thimerosal (Merthiolate)

    注意事项

    Biohazard Informations: This product contains thimerosal which is hazardous.

    储存条件

    4 °C/-20 °C

    储存方法

    Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
  • 抗原

    F13A1 (Coagulation Factor XIII, A1 Polypeptide (F13A1))

    别名

    Factor XIIIa

    背景

    This gene encodes the coagulation factor XIII A subunit.Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade.Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits.The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules.Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin.Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII.This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot.It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin.Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits, and type II deficiency, characterized by the lack of the A subunit alone.These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion.[provided by RefSeq]

    分子量

    83 kDa

    基因ID

    2162

    NCBI登录号

    NP_000120, NM_000129
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