ATRX 抗体 (AA 2161-2413)
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北京 101111
Quick Overview for ATRX 抗体 (AA 2161-2413) (ABIN1886208)
抗原
See all ATRX 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 2161-2413
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纯化方法
- Purified by antigen-affinity chromatography.
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免疫原
- Recombinant protein fragment contain a sequence corresponding to a region within amino acids 2161 and 2413 of ATRX
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应用备注
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Suggested dilutions:
Western blotting: 1.500-1.3000
Immunohistochemistry: 1.100-1.250
Immunofluorescence: 1.100-1.200 -
限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- 0.1 M Tris-buffered saline with 10 % Glycerol (pH 7.0).0.01 % Thimerosal was added as a preservative.
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储存液
- Thimerosal (Merthiolate)
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注意事项
- Biohazard Informations: This product contains thimerosal which is hazardous.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
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- ATRX (helicase 2, X-linked (ATRX))
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别名
- ATRX
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背景
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The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins.The mutations of this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome.These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes.This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis.Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.[provided by RefSeq]
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分子量
- 283 kDa
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基因ID
- 546
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NCBI登录号
- NM_000489, NP_000480
抗原
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