BCCIP
适用: 人
IF (p), IF (cc)
宿主: 兔
Polyclonal
AbBy Fluor® 680
应用备注
Suggested dilutions: Western blotting: 1.500-1.3000 Immunofluorescence: 1.100-1.200
限制
仅限研究用
状态
Liquid
缓冲液
0.1 M Tris-buffered saline with 10 % Glycerol (pH 7.0).0.01 % Thimerosal was added as a preservative.
储存液
Thimerosal (Merthiolate)
注意事项
Biohazard Informations: This product contains thimerosal which is hazardous.
储存条件
4 °C/-20 °C
储存方法
Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
抗原
BCCIP
(BRCA2 and CDKN1A Interacting Protein (BCCIP))
背景
This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins.It is an evolutionarily conserved nuclear protein with multiple interacting domains.The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium.Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21.This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression.Multiple transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq]