TFIID(SI-1) (AA 158-339) 抗体
The 兔 多克隆 anti-TFIID(SI-1) antibody is suitable to detect TFIID(SI-1) in samples from 人. It has been validated for IHC 和 WB.
产品编号 ABIN1886075
发货至:
中国
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Contact Info
Our Local Distributor
中国
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北京 101111
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Beijing Economic Technological Development Area
Room 801-803
Quick Overview for TFIID(SI-1) (AA 158-339) 抗体 (ABIN1886075)
抗原
TFIID(SI-1)
适用
人
宿主
兔
克隆类型
多克隆
应用范围
Immunohistochemistry (IHC), Western Blotting (WB)
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抗原表位
- AA 158-339
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纯化方法
- Affinity purified by Protein A.
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免疫原
- Recombinant protein fragment contain a sequence corresponding to a region within amino acids 158 and 339 of Human TBP
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应用备注
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Suggested dilutions:
Western blotting: 1.500-1.3000
Immunohistochemistry: 1.100-1.250 -
限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- 0.1 M Tris-buffered saline with 10 % Glycerol (pH 7.0).0.01 % Thimerosal was added as a preservative.
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储存液
- Thimerosal (Merthiolate)
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注意事项
- Biohazard Informations: This product contains thimerosal which is hazardous.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
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- TFIID(SI-1)
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背景
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Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides.The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals.TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs.TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation.This gene encodes TBP, the TATA-binding protein.A distinctive feature of TBP is a long string of glutamines in the N-terminal.This region of the protein modulates the DNA binding activity of the C terminus, and modulation of DNA binding affects the rate of transcription complex formation and initiation of transcription.Mutations that expand the number of CAG repeats encoding this polyglutamine tract, and thus increase the length of the polyglutamine string, are associated with spinocerebellar ataxia 17, a neurodegenerative disorder classified as a polyglutamine disease.[provided by RefSeq]
Synonyms: GTF2D, SCA17, TFIID, GTF2D1, MGC117320, MGC126054, MGC126055 -
分子量
- 38 kDa
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基因ID
- 6908
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NCBI登录号
- NP_003185, NM_003194
抗原
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