ALPL 抗体 (AA 1-369)
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北京 101111
Quick Overview for ALPL 抗体 (AA 1-369) (ABIN1885918)
抗原
See all ALPL 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-369
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纯化方法
- Purified by antigen-affinity chromatography.
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免疫原
- Recombinant protein fragment contain a sequence corresponding to a region within amino acids 1 and 369 of alkaline phosphatase (liver/bone/kidney)
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应用备注
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Suggested dilutions:
Western blotting: 1.500-1.3000
Immunohistochemistry: 1.50-1.500 -
限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- 0.1 M Tris-buffered saline with 10 % Glycerol (pH 7.0).0.01 % Thimerosal was added as a preservative.
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储存液
- Thimerosal (Merthiolate)
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注意事项
- Biohazard Informations: This product contains thimerosal which is hazardous.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
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- ALPL (Alkaline Phosphatase, Liver/bone/kidney (ALPL))
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别名
- alkaline phosphatase(liver/bone/kidney)
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背景
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There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific).The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1.The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme.The exact physiological function of the alkaline phosphatases is not known.A proposed function of this form of the enzyme is matrix mineralization, however, mice that lack a functional form of this enzyme show normal skeletal development.This enzyme has been linked directly to hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects.The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms.Alternatively spliced transcript variants, which encode the same protein, have been identified for this gene.[provided by RefSeq]
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分子量
- 57 kDa
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基因ID
- 249
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NCBI登录号
- NM_000478, NP_000469
抗原
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