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IL-33 抗体

This anti-IL-33 antibody is a 小鼠 单克隆 antibody detecting IL-33 in WB, ELISA 和 IHC. Suitable for 人 和 小鼠.
产品编号 ABIN1885548
发货至: 中国

Quick Overview for IL-33 抗体 (ABIN1885548)

抗原

See all IL-33 (IL33) 抗体
IL-33 (IL33) (Interleukin 33 (IL33))

适用

  • 83
  • 46
  • 36
  • 9
  • 1
人, 小鼠

宿主

  • 99
  • 34
  • 4
  • 4
  • 2
  • 1
  • 1
小鼠

克隆类型

  • 105
  • 40
单克隆

标记

  • 87
  • 20
  • 12
  • 5
  • 4
  • 4
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
This IL-33 antibody is un-conjugated

应用范围

  • 96
  • 66
  • 50
  • 31
  • 27
  • 17
  • 14
  • 14
  • 14
  • 11
  • 9
  • 6
  • 5
  • 5
  • 4
  • 4
  • 4
  • 3
  • 2
  • 1
  • 1
Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
  • 纯化方法

    Immunoaffinity chromotography purified IgG

    免疫原

    Raised against the recombinant IL-33 protein.
  • 限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    PBS containing 0.02 % sodium azide.

    储存液

    Sodium azide

    注意事项

    WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

    储存条件

    -20 °C

    储存方法

    Can be stored at -20 °C, stable for one year.

    有效期

    12 months
  • 抗原

    IL-33 (IL33) (Interleukin 33 (IL33))

    别名

    IL-33

    背景

    Interleukin-33 (IL-33) is a recently identified member of the IL-1 family of cytokines whose other members include IL-1alphabeta, IL-1Ra and IL-18.Its receptor has been shown to be ST2, an IL-1 receptor family member that also acts as a negative regulator of TLR-IL-1R signaling and IL-1R accessory protein (IL-1RAcP).Receptor binding of IL-33 activates NF-kappaB and MAP kinases and induces the expression of TH2-associated cytokines such as IL-4, IL-5 and IL-6.Prolonged IL-33 treatment of mice led to the development of eosinophilia, splenomegaly, and severe pathological changes in mucosal organs such as lungs, esophagus and small intestine.Recent experiments have shown that IL-33 can also co-localize with heterochromatin and possesses transcriptional repressor activities, indicating that IL-33 may function as both a proinflammatory cytokine and an intracellular nuclear factor with transcriptional regulatory properties.Despite its predicted molecular weight, IL-33 will often run at higher molecular weight in SDS-PAGE.
    Synonyms: IL-33 (12B3C4), Interleukin-33, Nuclear factor from high endothelial venules, NFHEV

    NCBI登录号

    NP_254274

    途径

    Production of Molecular Mediator of Immune Response
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