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Filamin A 抗体 (AA 1-360)

This anti-Filamin A antibody is a 小鼠 单克隆 antibody detecting Filamin A in WB. Suitable for 人, 小鼠 和 大鼠. This Primary Antibody has been cited in 5+ publications.
产品编号 ABIN1882243
发货至: 中国

Quick Overview for Filamin A 抗体 (AA 1-360) (ABIN1882243)

抗原

See all Filamin A (FLNA) 抗体
Filamin A (FLNA) (Filamin A, alpha (FLNA))

适用

  • 108
  • 33
  • 22
  • 3
  • 2
  • 1
人, 小鼠, 大鼠

宿主

  • 100
  • 8
  • 1
小鼠

克隆类型

  • 88
  • 21
单克隆

标记

  • 50
  • 7
  • 5
  • 4
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
This Filamin A antibody is un-conjugated

应用范围

  • 57
  • 35
  • 34
  • 28
  • 28
  • 24
  • 16
  • 13
  • 10
  • 7
  • 6
  • 3
  • 2
  • 2
  • 1
Western Blotting (WB)

克隆位点

1273CT424-104-153
  • 抗原表位

    • 15
    • 15
    • 13
    • 6
    • 5
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-360

    纯化方法

    This antibody is purified through a protein G column, followed by dialysis against PBS.

    免疫原

    Purified His-tagged FLNA protein was used to produced this monoclonal antibody.

    亚型

    IgG1
  • 应用备注

    WB: 1:1000

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    有效期

    6 months
  • Campos, Rodriguez, Machado Leopoldino, Hait, Lopez Bergami, Castro, Sanchez, Maceyka, Spiegel, Alvarez: "Filamin A Expression Negatively Regulates Sphingosine-1-Phosphate-Induced NF-?B Activation in Melanoma Cells by Inhibition of Akt Signaling." in: Molecular and cellular biology, (2015) (PubMed).

    Li, Liu, Wang, Liu, Liu, Li, Wan, Wang, Zhang, Jin, Liu, Zhu, Liu: "Systematic mapping and functional analysis of a family of human epididymal secretory sperm-located proteins." in: Molecular & cellular proteomics : MCP, Vol. 9, Issue 11, pp. 2517-28, (2010) (PubMed).

    Chen, Zollo, Mazzarella, Ciccodicola, Chen, Zuo, Heiner, Burough, Repetto, Schlessinger, DUrso: "Long-range sequence analysis in Xq28: thirteen known and six candidate genes in 219.4 kb of high GC DNA between the RCP/GCP and G6PD loci." in: Human molecular genetics, Vol. 5, Issue 5, pp. 659-68, (1997) (PubMed).

    Patrosso, Repetto, Villa, Milanesi, Frattini, Faranda, Mancini, Maestrini, Toniolo, Vezzoni: "The exon-intron organization of the human X-linked gene (FLN1) encoding actin-binding protein 280." in: Genomics, Vol. 21, Issue 1, pp. 71-6, (1994) (PubMed).

    Gorlin, Yamin, Egan, Stewart, Stossel, Kwiatkowski, Hartwig: "Human endothelial actin-binding protein (ABP-280, nonmuscle filamin): a molecular leaf spring." in: The Journal of cell biology, Vol. 111, Issue 3, pp. 1089-105, (1990) (PubMed).

  • 抗原

    Filamin A (FLNA) (Filamin A, alpha (FLNA))

    别名

    FLNA

    背景

    Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis.

    分子量

    280739

    NCBI登录号

    NP_001104026, NP_001447

    UniProt

    P21333

    途径

    TCR Signaling, Maintenance of Protein Location
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