USP2 抗体 (AA 245-275)
(3 references)Quick Overview for USP2 抗体 (AA 245-275) (ABIN1882149)
抗原
See all USP2 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 245-275
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预测反应
- B, M, Rat
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纯化方法
- This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
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免疫原
- This USP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 245-275 amino acids from human USP2.
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亚型
- Ig Fraction
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anti-Ubiquitin Specific Peptidase 2 (USP2) (AA 508-538), (C-Term) antibody
USP2 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB4417 unconjugated
anti-Ubiquitin Specific Peptidase 2 (USP2) (AA 71-101), (N-Term) antibodyUSP2 适用: 人, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB4202 unconjugated
anti-Ubiquitin Specific Peptidase 2 (USP2) (AA 200-430), (C-Term) antibodyUSP2 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 2 (USP2) antibodyUSP2 适用: 人, 小鼠, 大鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 2 (USP2) (AA 1-605) antibodyUSP2 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 2 (USP2) (AA 9-265) antibodyUSP2 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 2 (USP2) (AA 1-258) antibodyUSP2 适用: 人, Green Monkey WB 宿主: 小鼠 Monoclonal 1738CT331-50-87 unconjugated
anti-Ubiquitin Specific Peptidase 2 (USP2) (AA 371-420) antibodyUSP2 适用: 人, 犬, 马, 兔, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 2 (USP2) (AA 1-605) antibodyUSP2 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Ubiquitin Specific Peptidase 2 (USP2) (AA 71-120) antibodyUSP2 适用: 人, 大鼠, 犬, Cow, 猴 WB 宿主: 兔 Polyclonal unconjugated
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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有效期
- 6 months
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: "USP2a protein deubiquitinates and stabilizes the circadian protein CRY1 in response to inflammatory signals." in: The Journal of biological chemistry, Vol. 287, Issue 30, pp. 25280-91, (2012) (PubMed).
: "Down-regulation of the de-ubiquitinating enzyme ubiquitin-specific protease 2 contributes to tumor necrosis factor-alpha-induced hepatocyte survival." in: The Journal of biological chemistry, Vol. 284, Issue 1, pp. 495-504, (2008) (PubMed).
: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ..." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, (2002) (PubMed).
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: "USP2a protein deubiquitinates and stabilizes the circadian protein CRY1 in response to inflammatory signals." in: The Journal of biological chemistry, Vol. 287, Issue 30, pp. 25280-91, (2012) (PubMed).
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- USP2 (Ubiquitin Specific Peptidase 2 (USP2))
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别名
- USP2
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背景
- Modification of target proteins by ubiquitin participates in a wide array of biological functions. Proteins destined for degradation or processing via the 26 S proteasome are coupled to multiple copies of ubiquitin. However, attachment of ubiquitin or ubiquitin-related molecules may also result in changes in subcellular distribution or modification of protein activity. An additional level of ubiquitin regulation, deubiquitination, is catalyzed by proteases called deubiquitinating enzymes, which fall into four distinct families. Ubiquitin C-terminal hydrolases, ubiquitin-specific processing proteases (USPs),1 OTU-domain ubiquitin-aldehyde-binding proteins, and Jab1/Pad1/MPN-domain-containing metallo-enzymes. Among these four families, USPs represent the most widespread and represented deubiquitinating enzymes across evolution. USPs tend to release ubiquitin from a conjugated protein. They display similar catalytic domains containing conserved Cys and His boxes but divergent N-terminal and occasionally C-terminal extensions, which are thought to function in substrate recognition, subcellular localization, and protein-protein interactions.
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分子量
- 68072
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NCBI登录号
- NP_001230688, NP_004196, NP_741994
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UniProt
- O75604
抗原
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