TK2 抗体 (N-Term)
This anti-TK2 antibody is a 兔 多克隆 antibody detecting TK2 in WB. Suitable for 人 和 小鼠.
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Quick Overview for TK2 抗体 (N-Term) (ABIN1882141)
抗原
See all TK2 products
TK2
(Thymidine Kinase 2, Mitochondrial (TK2))
适用
人, 小鼠
宿主
兔
克隆类型
多克隆
应用范围
Western Blotting (WB)
克隆位点
RB5434
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抗原表位
- AA 8-38, N-Term
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纯化方法
- This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
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免疫原
- This Thymidine Kinase 2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 8-38 amino acids from the N-terminal region of human Thymidine Kinase 2.
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亚型
- Ig Fraction
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应用备注
- WB: 1:1000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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有效期
- 6 months
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- TK2 (Thymidine Kinase 2, Mitochondrial (TK2))
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背景
- Thymidine kinase-2 (TK2) is a deoxyribonucleoside kinase that phosphorylates thymidine, deoxycytidine, and deoxyuridine, and also phosphorylates antiviral and anticancer nucleoside analogs. Both recombinant and native forms of the enzyme have broad substrate specificity and complex kinetics, suggesting that it may play a role in the activation of chemotherapeutic nucleoside analogs. The highest levels of expression are observed in testis and ovary. The main supply of deoxyribonucleotides (dNTPs) for mitochondrial DNA synthesis comes from the salvage pathway initiated by deoxyguanosine kinase (DGK) and TK2. The association of mitochondrial DNA depletion with mutations in the genes encoding these 2 kinases suggests that the salvage pathway enzymes are involved in the maintenance of balanced mitochondrial dNTP pools.
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分子量
- 31005
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NCBI登录号
- NP_001166114, NP_001166115, NP_001258864, NP_004605
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UniProt
- O00142
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途径
- Mitotic G1-G1/S Phases
抗原
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