HTRA3 抗体 (N-Term)
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北京 101111
Quick Overview for HTRA3 抗体 (N-Term) (ABIN1882095)
抗原
See all HTRA3 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 112-144, N-Term
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纯化方法
- This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
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免疫原
- This HtrA3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 112-144 amino acids from the N-terminal region of human HtrA3.
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亚型
- Ig Fraction
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anti-HtrA Serine Peptidase 3 (HTRA3) (AA 344-453) antibody
HTRA3 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1F2 unconjugated
anti-HtrA Serine Peptidase 3 (HTRA3) (AA 334-453) antibodyHTRA3 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-HtrA Serine Peptidase 3 (HTRA3) antibodyHTRA3 适用: 人, 大鼠, 小鼠 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-HtrA Serine Peptidase 3 (HTRA3) (AA 214-453) antibodyHTRA3 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-HtrA Serine Peptidase 3 (HTRA3) antibodyHTRA3 适用: 人, 大鼠, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-HtrA Serine Peptidase 3 (HTRA3) (AA 330-362), (C-Term) antibodyHTRA3 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-HtrA Serine Peptidase 3 (HTRA3) (Middle Region) antibodyHTRA3 适用: 人, 大鼠, 小鼠, 豚鼠, 犬, 马 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100. IHC-P: 1:50~100
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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有效期
- 6 months
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: "Changes in mRNA and protein levels of human HtrA1, HtrA2 and HtrA3 in ovarian cancer." in: Clinical biochemistry, Vol. 41, Issue 7-8, pp. 561-9, (2008) (PubMed).
: "Implications of the serine protease HtrA1 in amyloid precursor protein processing." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 17, pp. 6021-6, (2005) (PubMed).
: "Identification and cloning of two isoforms of human high-temperature requirement factor A3 (HtrA3), characterization of its genomic structure and comparison of its tissue distribution with HtrA1 and ..." in: The Biochemical journal, Vol. 371, Issue Pt 1, pp. 39-48, (2003) (PubMed).
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: "Changes in mRNA and protein levels of human HtrA1, HtrA2 and HtrA3 in ovarian cancer." in: Clinical biochemistry, Vol. 41, Issue 7-8, pp. 561-9, (2008) (PubMed).
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- HTRA3 (HtrA Serine Peptidase 3 (HTRA3))
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别名
- HtrA3
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背景
- Insulin-like growth factors (IGFs) stimulate the proliferation and differentiation of a vast number of cell types. The action of the growth factors is mediated and controlled by a complex system of components, including several proteases that cleave the IGF-Binding Proteins. HtrA1 is a 480 aa protein that contains an N-terminus homologous to MAC25 (IGFBP7) with a conserved Kazal-type serine protease inhibitor motif, as well as a C-terminal PDZ domain. Semiquantitative RT-PCR and immunoblot analyses showed an approximately 7-fold increase of PRSS11 in osteoarthritis cartilage compared with controls. HTRA2 is released from mitochondria and inhibits the function of XIAP by direct binding in a way similar to SMAC. Moreover, when overexpressed extramitochondrially, HTRA2 induced atypical cell death, which was neither accompanied by a significant increase in caspase activity nor inhibited by caspase inhibitors, including XIAP. A catalytically inactive mutant of HTRA2, however, did not induce cell death. Suzuki et al. (2001) concluded that HTRA2 is a SMAC-like inhibitor of IAP (inhibitor of apoptosis proteins) activity with a serine protease-dependent cell death-inducing activity.
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分子量
- 48608
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NCBI登录号
- NP_444272
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UniProt
- P83110
抗原
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