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HTRA3 抗体 (N-Term)

Name: HTRA3 抗体 (N-Term)
SKU: ABIN1882095
Availability: OutOfStock

This anti-HTRA3 antibody is a 兔多克隆 antibody detecting HTRA3 in WB 和 IHC (p). Suitable for 人和大鼠. This Primary Antibody has been cited in 3+ publications.

Anti-HtrA3 Antibody (N-term) at 1:1000 dilution + human heart lysate Lysates/proteins at 20 μg per lane. (HTRA3 抗体 (N-Term))

Formalin-fixed and paraffin-embedded human placenta tissue reacted with HtrA3 antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. (HTRA3 抗体 (N-Term))

IHC (p)

The anti-HtrA3 N-term Pab (ABIN1882095 and ABIN2846350) is used in Western blot to detect HtrA3 in rat testis tissue lysate. (HTRA3 抗体 (N-Term))

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. (HTRA3 抗体 (N-Term))

IHC (p)

4 images

(3 references)

产品编号 ABIN1882095

发货至: 中国

Quick Overview for HTRA3 抗体 (N-Term) (ABIN1882095)

抗原

See all HTRA3 抗体

HTRA3 (HtrA Serine Peptidase 3 (HTRA3))

适用

人, 大鼠

宿主

兔

克隆类型

多克隆

标记

This HTRA3 antibody is un-conjugated

应用范围

Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

克隆位点

RB2322

抗原表位
2

1

1

1

1

1

1

1

1
AA 112-144, N-Term

纯化方法

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

免疫原

This HtrA3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 112-144 amino acids from the N-terminal region of human HtrA3.

亚型

Ig Fraction
anti-HtrA Serine Peptidase 3 (HTRA3) (AA 344-453) antibody
HTRA3 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1F2 unconjugated

anti-HtrA Serine Peptidase 3 (HTRA3) antibody
HTRA3 适用: 人, 大鼠, 小鼠 IHC, ELISA 宿主: 兔 Polyclonal unconjugated

anti-HtrA Serine Peptidase 3 (HTRA3) (AA 214-453) antibody
HTRA3 适用: 人 WB 宿主: 兔 Polyclonal unconjugated

anti-HtrA Serine Peptidase 3 (HTRA3) (AA 334-453) antibody
HTRA3 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-HtrA Serine Peptidase 3 (HTRA3) (AA 188-237) antibody
HTRA3 适用: 人, 豚鼠, 猴 WB 宿主: 兔 Polyclonal unconjugated

anti-HtrA Serine Peptidase 3 (HTRA3) antibody
HTRA3 适用: 人 WB 宿主: 兔 Polyclonal unconjugated

anti-HtrA Serine Peptidase 3 (HTRA3) (AA 112-144) antibody
HTRA3 适用: 人, 大鼠 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-HtrA Serine Peptidase 3 (HTRA3) antibody
HTRA3 适用: 人, 大鼠, 小鼠 WB 宿主: 兔 Polyclonal unconjugated

anti-HtrA Serine Peptidase 3 (HTRA3) (AA 330-362), (C-Term) antibody
HTRA3 适用: 人 WB 宿主: 兔 Polyclonal unconjugated

anti-HtrA Serine Peptidase 3 (HTRA3) (Middle Region) antibody
HTRA3 适用: 人, 大鼠, 小鼠, 豚鼠, 犬, 马 WB 宿主: 兔 Polyclonal unconjugated

应用备注

WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100. IHC-P: 1:50~100

限制

仅限研究用
状态

Liquid

缓冲液

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

有效期

6 months
Narkiewicz, Klasa-Mazurkiewicz, Zurawa-Janicka, Skorko-Glonek, Emerich, Lipinska: "Changes in mRNA and protein levels of human HtrA1, HtrA2 and HtrA3 in ovarian cancer." in: Clinical biochemistry, Vol. 41, Issue 7-8, pp. 561-9, (2008) (PubMed).

Grau, Baldi, Bussani, Tian, Stefanescu, Przybylski, Richards, Jones, Shridhar, Clausen, Ehrmann: "Implications of the serine protease HtrA1 in amyloid precursor protein processing." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 17, pp. 6021-6, (2005) (PubMed).

Nie, Hampton, Li, Findlay, Salamonsen et al.: "Identification and cloning of two isoforms of human high-temperature requirement factor A3 (HtrA3), characterization of its genomic structure and comparison of its tissue distribution with HtrA1 and ..." in: The Biochemical journal, Vol. 371, Issue Pt 1, pp. 39-48, (2003) (PubMed).
抗原

HTRA3 (HtrA Serine Peptidase 3 (HTRA3))

别名

HtrA3

背景

Insulin-like growth factors (IGFs) stimulate the proliferation and differentiation of a vast number of cell types. The action of the growth factors is mediated and controlled by a complex system of components, including several proteases that cleave the IGF-Binding Proteins. HtrA1 is a 480 aa protein that contains an N-terminus homologous to MAC25 (IGFBP7) with a conserved Kazal-type serine protease inhibitor motif, as well as a C-terminal PDZ domain. Semiquantitative RT-PCR and immunoblot analyses showed an approximately 7-fold increase of PRSS11 in osteoarthritis cartilage compared with controls. HTRA2 is released from mitochondria and inhibits the function of XIAP by direct binding in a way similar to SMAC. Moreover, when overexpressed extramitochondrially, HTRA2 induced atypical cell death, which was neither accompanied by a significant increase in caspase activity nor inhibited by caspase inhibitors, including XIAP. A catalytically inactive mutant of HTRA2, however, did not induce cell death. Suzuki et al. (2001) concluded that HTRA2 is a SMAC-like inhibitor of IAP (inhibitor of apoptosis proteins) activity with a serine protease-dependent cell death-inducing activity.

分子量

48608

NCBI登录号

NP_444272

UniProt

P83110