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GRK4 抗体 (C-Term)

Name: GRK4 抗体 (C-Term)
SKU: ABIN1882085
Availability: OutOfStock

This anti-GRK4 antibody is a 兔多克隆 antibody detecting GRK4 in WB 和 IHC (p). Suitable for 人. This Primary Antibody has been cited in 6+ publications.

Western blot analysis of anti-GRK4 Pab (ABIN1882085 and ABIN2841170) in HL60 cell lysate. (GRK4 抗体 (C-Term))

Formalin-fixed and paraffin-embedded human testis tissue reacted with GRK4 antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. (GRK4 抗体 (C-Term))

IHC (p)

2 images

(6 references)

产品编号 ABIN1882085

发货至: 中国

Quick Overview for GRK4 抗体 (C-Term) (ABIN1882085)

抗原

See all GRK4 抗体

GRK4 (G Protein-Coupled Receptor Kinase 4 (GRK4))

适用

人

宿主

兔

克隆类型

多克隆

标记

This GRK4 antibody is un-conjugated

应用范围

Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

克隆位点

RB0901

Discover our top product GRK4 Primary Antibody

抗原表位
8

4

2

2

1

1

1

1

1

1
AA 549-577, C-Term

纯化方法

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

免疫原

This GRK4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 549-577 amino acids from the C-terminal region of human GRK4.

亚型

Ig Fraction
anti-G Protein-Coupled Receptor Kinase 4 (GRK4) (AA 1-245) antibody
GRK4 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-G Protein-Coupled Receptor Kinase 4 (GRK4) (AA 36-145) antibody
GRK4 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 6D12 unconjugated

anti-G Protein-Coupled Receptor Kinase 4 (GRK4) (AA 187-449) antibody
GRK4 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-G Protein-Coupled Receptor Kinase 4 (GRK4) (AA 36-145) antibody
GRK4 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated

anti-G Protein-Coupled Receptor Kinase 4 (GRK4) (AA 36-145) antibody
GRK4 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2C5 unconjugated

anti-G Protein-Coupled Receptor Kinase 4 (GRK4) antibody
GRK4 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-G Protein-Coupled Receptor Kinase 4 (GRK4) (AA 36-145) antibody
GRK4 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 6D12 unconjugated

anti-G Protein-Coupled Receptor Kinase 4 (GRK4) (N-Term) antibody
GRK4 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated

anti-G Protein-Coupled Receptor Kinase 4 (GRK4) (AA 359-408) antibody
GRK4 适用: 人, 小鼠, 大鼠, Cow, 马, 猴 WB 宿主: 兔 Polyclonal unconjugated

anti-G Protein-Coupled Receptor Kinase 4 (GRK4) (AA 243-292) antibody
GRK4 适用: 人, 小鼠, Cow, 马, 斑马鱼, 兔, Pig WB 宿主: 兔 Polyclonal unconjugated

应用备注

WB: 1:1000. IHC-P: 1:10~50

限制

仅限研究用
状态

Liquid

缓冲液

Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

有效期

6 months
Villar, Jones, Armando, Palmes-Saloma, Yu, Pascua, Keever, Arnaldo, Wang, Luo, Felder, Jose: "G protein-coupled receptor kinase 4 (GRK4) regulates the phosphorylation and function of the dopamine D3 receptor." in: The Journal of biological chemistry, Vol. 284, Issue 32, pp. 21425-34, (2009) (PubMed).

Perroy, Adam, Qanbar, Chénier, Bouvier: "Phosphorylation-independent desensitization of GABA(B) receptor by GRK4." in: The EMBO journal, Vol. 22, Issue 15, pp. 3816-24, (2003) (PubMed).

Watanabe, Xu, Bengra, Jose, Felder: "Desensitization of human renal D1 dopamine receptors by G protein-coupled receptor kinase 4." in: Kidney international, Vol. 62, Issue 3, pp. 790-8, (2002) (PubMed).

Sallese, Mariggiò, Collodel, Moretti, Piomboni, Baccetti, De Blasi: "G protein-coupled receptor kinase GRK4. Molecular analysis of the four isoforms and ultrastructural localization in spermatozoa and germinal cells." in: The Journal of biological chemistry, Vol. 272, Issue 15, pp. 10188-95, (1997) (PubMed).

Premont, Macrae, Stoffel, Chung, Pitcher, Ambrose, Inglese, MacDonald, Lefkowitz: "Characterization of the G protein-coupled receptor kinase GRK4. Identification of four splice variants." in: The Journal of biological chemistry, Vol. 271, Issue 11, pp. 6403-10, (1996) (PubMed).

Sallese, Lombardi, De Blasi: "Two isoforms of G protein-coupled receptor kinase 4 identified by molecular cloning." in: Biochemical and biophysical research communications, Vol. 199, Issue 2, pp. 848-54, (1994) (PubMed).
抗原

GRK4 (G Protein-Coupled Receptor Kinase 4 (GRK4))

别名

GRK4

背景

Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The AGC kinase group consists of 63 kinases including the cyclic nucleotide-regulated protein kinase (PKA & PKG) family, the diacylglycerol-activated/phospholipid-dependent protein kinase C (PKC) family, the related to PKA and PKC (RAC/Akt) protein kinase family, the kinases that phosphorylate G protein-coupled receptors family (ARK), and the kinases that phosphorylate ribosomal protein S6 family (RSK).

分子量

66583

NCBI登录号

NP_001004056, NP_001004057, NP_892027

UniProt

P32298

途径

Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling