FNTA 抗体 (C-Term)
(5 references)Quick Overview for FNTA 抗体 (C-Term) (ABIN1882083)
抗原
See all FNTA 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 330-360, C-Term
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预测反应
- B, M, Rat
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纯化方法
- This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
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免疫原
- This FNTA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 330-360 amino acids from the C-terminal region of human FNTA.
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亚型
- Ig Fraction
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anti-Farnesyltransferase, CAAX Box, alpha (FNTA) (AA 51-366) antibody
FNTA 适用: 人 WB, ELISA, IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Farnesyltransferase, CAAX Box, alpha (FNTA) (AA 1-214) antibodyFNTA 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Farnesyltransferase, CAAX Box, alpha (FNTA) antibodyFNTA 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Farnesyltransferase, CAAX Box, alpha (FNTA) (N-Term) antibodyFNTA 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Farnesyltransferase, CAAX Box, alpha (FNTA) (C-Term) antibodyFNTA 适用: 人, 大鼠, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-Farnesyltransferase, CAAX Box, alpha (FNTA) (AA 280-379) antibodyFNTA 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Farnesyltransferase, CAAX Box, alpha (FNTA) (N-Term) antibodyFNTA 适用: 人, 小鼠, 大鼠, Cow, 兔 WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB: 1:1000. IHC-P: 1:50~100
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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有效期
- 6 months
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: "Upregulation of geranylgeranyltransferase I in bronchial smooth muscle of mouse experimental asthma: its inhibition by lovastatin." in: Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi, Vol. 46, Issue 1, pp. 57-64, (2010) (PubMed).
: "The p21(RAS) farnesyltransferase alpha subunit in TGF-beta and activin signaling." in: Science (New York, N.Y.), Vol. 271, Issue 5252, pp. 1120-2, (1996) (PubMed).
: "cDNA cloning and expression of rat and human protein geranylgeranyltransferase type-I." in: The Journal of biological chemistry, Vol. 269, Issue 5, pp. 3175-80, (1994) (PubMed).
: "cDNA cloning of the two subunits of human CAAX farnesyltransferase and chromosomal mapping of FNTA and FNTB loci and related sequences." in: Genomics, Vol. 18, Issue 1, pp. 105-12, (1994) (PubMed).
: "Characterization of recombinant human farnesyl-protein transferase: cloning, expression, farnesyl diphosphate binding, and functional homology with yeast prenyl-protein transferases." in: Biochemistry, Vol. 32, Issue 19, pp. 5167-76, (1993) (PubMed).
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: "Upregulation of geranylgeranyltransferase I in bronchial smooth muscle of mouse experimental asthma: its inhibition by lovastatin." in: Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi, Vol. 46, Issue 1, pp. 57-64, (2010) (PubMed).
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- FNTA (Farnesyltransferase, CAAX Box, alpha (FNTA))
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别名
- FNTA
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背景
- FNTA, also known as CAAX farnesyltransferase (FTase), attaches a farnesyl group from farnesyl pyrophosphate to cysteine residues at the fourth position from the C terminus of proteins that end in the so-called CAAX box, where C is cysteine, A is usually but not always an aliphatic amino acid, and X is typically methionine or serine. This type of posttranslational modification provides a mechanism for membrane localization of proteins that lack a transmembrane domain. This enzyme has the remarkable property of farnesylating peptides as short as four residues in length that conform to the CAAX consensus sequence. FNTA is also a specific cytoplasmic interactor of the transforming growth factor-beta and activin type I receptors. It is likely to be a key component of the signaling pathway which involves p21ras, an important substrate for farnesyltransferase.
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分子量
- 44409
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NCBI登录号
- NP_002018
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UniProt
- P49354
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途径
- Response to Water Deprivation, Regulation of G-Protein Coupled Receptor Protein Signaling
抗原
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