TXN 抗体 (C-Term)
Quick Overview for TXN 抗体 (C-Term) (ABIN1881960)
抗原
See all TXN 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 66-94, C-Term
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预测反应
- B, M, Pig, Rb, Rat
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纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
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免疫原
- This TXN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 66-94 amino acids from the C-terminal region of human TXN.
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亚型
- Ig Fraction
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应用备注
- WB: 1:1000. IHC-P: 1:25. IHC-P: 1:25
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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有效期
- 6 months
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: "Butaselen prevents hepatocarcinogenesis and progression through inhibiting thioredoxin reductase activity." in: Redox biology, Vol. 14, pp. 237-249, (2018) (PubMed).
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: "Butaselen prevents hepatocarcinogenesis and progression through inhibiting thioredoxin reductase activity." in: Redox biology, Vol. 14, pp. 237-249, (2018) (PubMed).
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- TXN (Thioredoxin (TXN))
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别名
- TXN
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背景
- Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity. ADF augments the expression of the interleukin-2 receptor TAC (IL2R/P55).
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分子量
- 11737
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NCBI登录号
- NP_001231867, NP_003320
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UniProt
- P10599
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途径
- Carbohydrate Homeostasis, Cell RedoxHomeostasis
抗原
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