CASK 抗体 (AA 589-616)
Quick Overview for CASK 抗体 (AA 589-616) (ABIN1881710)
抗原
See all CASK 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 589-616
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预测反应
- H, M
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纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
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免疫原
- This Rat Cask antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 589-616 amino acids from the Central region of rat Cask.
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亚型
- Ig Fraction
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应用备注
- WB: 1:1000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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有效期
- 6 months
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CASK participates in alternative tripartite complexes in which Mint 1 competes for binding with caskin 1, a novel CASK-binding protein." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 22, Issue 11, pp. 4264-73, (2002) (PubMed).
: "Postsynaptic targeting of alternative postsynaptic density-95 isoforms by distinct mechanisms." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 22, Issue 15, pp. 6415-25, (2002) (PubMed).
: "Nuclear translocation and transcription regulation by the membrane-associated guanylate kinase CASK/LIN-2." in: Nature, Vol. 404, Issue 6775, pp. 298-302, (2000) (PubMed).
: "A tripartite protein complex with the potential to couple synaptic vesicle exocytosis to cell adhesion in brain." in: Cell, Vol. 94, Issue 6, pp. 773-82, (1998) (PubMed).
: "CASK: a novel dlg/PSD95 homolog with an N-terminal calmodulin-dependent protein kinase domain identified by interaction with neurexins." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 16, Issue 8, pp. 2488-94, (1996) (PubMed).
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CASK participates in alternative tripartite complexes in which Mint 1 competes for binding with caskin 1, a novel CASK-binding protein." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 22, Issue 11, pp. 4264-73, (2002) (PubMed).
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- CASK (Calcium/calmodulin-Dependent serine Protein Kinase (MAGUK Family) (CASK))
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别名
- Cask
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背景
- Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Contributes to neural development and regulation of gene expression via interaction with the transcription factor TRB1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins, and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1.
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分子量
- 103259
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NCBI登录号
- NP_071520
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UniProt
- Q62915
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途径
- Synaptic Vesicle Exocytosis
抗原
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