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PPM1F 抗体 (AA 275-303)

This anti-PPM1F antibody is a 兔 多克隆 antibody detecting PPM1F in WB. Suitable for 人. This Primary Antibody has been cited in 4+ publications.
产品编号 ABIN1881678
发货至: 中国

Quick Overview for PPM1F 抗体 (AA 275-303) (ABIN1881678)

抗原

See all PPM1F 抗体
PPM1F (Protein Phosphatase 1F (PP2C Domain Containing) (PPM1F))

适用

  • 51
  • 2
  • 1

宿主

  • 44
  • 7

克隆类型

  • 47
  • 4
多克隆

标记

  • 27
  • 5
  • 3
  • 3
  • 3
  • 3
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
This PPM1F antibody is un-conjugated

应用范围

  • 36
  • 27
  • 21
  • 12
  • 8
  • 4
  • 4
  • 4
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB)

克隆位点

RB41919
  • 抗原表位

    • 11
    • 8
    • 7
    • 6
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 275-303

    纯化方法

    This antibody is purified through a protein A column, followed by peptide affinity purification.

    免疫原

    This PPM1F antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 275-303 amino acids from the Central region of human PPM1F.

    亚型

    Ig Fraction
  • 应用备注

    WB: 1:1000

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    有效期

    6 months
  • Harvey, Banga, Ozer: "Regulation of the multifunctional Ca2+/calmodulin-dependent protein kinase II by the PP2C phosphatase PPM1F in fibroblasts." in: The Journal of biological chemistry, Vol. 279, Issue 23, pp. 24889-98, (2004) (PubMed).

    Koh, Tan, Manser, Lim: "The p21-activated kinase PAK is negatively regulated by POPX1 and POPX2, a pair of serine/threonine phosphatases of the PP2C family." in: Current biology : CB, Vol. 12, Issue 4, pp. 317-21, (2002) (PubMed).

    Tan, Chan, Tan, Yu: "The Caenorhabditis elegans sex-determining protein FEM-2 and its human homologue, hFEM-2, are Ca2+/calmodulin-dependent protein kinase phosphatases that promote apoptosis." in: The Journal of biological chemistry, Vol. 276, Issue 47, pp. 44193-202, (2001) (PubMed).

    Kitani, Ishida, Okuno, Takeuchi, Kameshita, Fujisawa: "Molecular cloning of Ca2+/calmodulin-dependent protein kinase phosphatase." in: Journal of biochemistry, Vol. 125, Issue 6, pp. 1022-8, (1999) (PubMed).

  • 抗原

    PPM1F (Protein Phosphatase 1F (PP2C Domain Containing) (PPM1F))

    别名

    PPM1F

    背景

    The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase can interact with Rho guanine nucleotide exchange factors (PIX), and thus block the effects of p21-activated kinase 1 (PAK), a protein kinase mediating biological effects downstream of Rho GTPases. Calcium/calmodulin-dependent protein kinase II gamma (CAMK2G/CAMK-II) is found to be one of the substrates of this phosphatase. The overexpression of this phosphatase or CAMK2G has been shown to mediate caspase-dependent apoptosis. An alternatively spliced transcript variant has been identified, but its full-length nature has not been determined.

    分子量

    49831

    NCBI登录号

    NP_055449

    UniProt

    P49593

    途径

    Positive Regulation of Endopeptidase Activity
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